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Research/Clinical Data

Clinical Data

Product Reference Bibliography for Osteoben®

  • National Osteoporosis Foundation. Clinician's Guide to Prevention and Treatment of Osteoporosis.
    Washington, DC: National Osteoporosis Foundation; 2010.
  • Iqbal MM. Osteoporosis:epidemiology, diagnosis, and treatment.
    South Med J. 2000 Jan;93(1):2-18.
  • International Osteoporosis Foundation. Feb 23, 2010.
    www.iofbonehealth.org
  • Klinger B, Lee R. Integrative Medicine,
    McGraw-Hill, New York, 2004, pp549-566.
  • Booth SL, Dallal G, Shea MK, Gundberg C, Peterson JW, Dawson-Hughes B.
    Effect of vitamin K supplementation on bone loss in elderly men and women. J Clin Endocrinol Metab. 2008
    Apr;93(4):1217-23.
  • Leveille SG, LaCroix AZ, Koepsell TD, Beresford SA, Van Belle G, Buchner DM.
    Dietary vitamin C and bone mineral density in postmenopausal women in Washington State, USA. J Epidemiol
    Community Health. 1997 Oct;51(5):479-85.
  • Sahni S, Hannan MT, Gagnon D, Blumberg J, Cupples LA, Kiel DP, Tucker KL.
  • Booth SL, Dallal G, Shea MK, Gundberg C, Peterson JW, Dawson-Hughes B.
    Effect of vitamin K supplementation on bone loss in elderly men and women. J Clin Endocrinol Metab. 2008
    Apr;93(4):1217-23.
  • Leveille SG, LaCroix AZ, Koepsell TD, Beresford SA, Van Belle G, Buchner DM.
    Dietary vitamin C and bone mineral density in postmenopausal women in Washington State, USA. J Epidemiol
    Community Health. 1997 Oct;51(5):479-85.
  • Sahni S, Hannan MT, Gagnon D, Blumberg J, Cupples LA, Kiel DP, Tucker KL.

Clinical Data

Product Reference Bibliography for Arthoben®

  • Berg RA, Kerr JS. Nutritional aspects of collagen metabolism.
    Annu Rev Nutr. 1992;12:369-90. Review. PubMed PMID: 1503810.
  • Oesser S, Adam M, Babel W, Seifert J. Oral administration of (14)C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL).
    J Nutr. 1999 Oct;129(10):1891-5. PubMed PMID: 10498764.
  • EASTOE JE.The amino acid composition of mammalian collagen and gelatin.
    Biochem J. 1955 Dec;61(4):589-600. PubMed PMID: 13276342; PubMed Central PMCID: PMC1215839.
  • Barbul A. Proline precursors to sustain Mammalian collagen synthesis.
    J Nutr. 2008 Oct;138(10):2021S-2024S. PubMed PMID: 18806118.
  • de Almeida Jackix E, Cúneo F, Amaya-Farfan J, de Assunção JV, Quintaes KD. A food supplement of hydrolyzed collagen improves compositional and biodynamic characteristics of vertebrae in ovariectomized rats.
    J Med Food. 2010 Dec;13(6):1385-90. Epub 2010 Sep 27. PubMed PMID: 20874246.
  • Nomura Y, Oohashi K, Watanabe M, Kasugai S Increase in bone mineral density through oral administration of shark gelatin to ovariectomized rats.
    Nutrition.2005 Nov-Dec;21(11-12):1120-6. PubMed PMID: 16308135.
  • Oesser S, Raabe A, Schunck M, 2007. Orally administered collagen hydrolysate halts the progression of osteoarthritis in STR/ort mice.
    Osteoarthritis and Cartilage. Vol. 15, (Supplement C), 94 – 95
  • USDA National Nutrient Database for Standard Reference, Release 25. http://www.ars.usda.gov/Services/docs.htm?docid=8964
  • ZIFF M, KIBRICK A, DRESNER E, GRIBETZ HJ. Excretion of hydroxyproline in patients with rheumatic and non-rheumatic diseases.
    J Clin Invest. 1956 Jun;35(6):579-87. PubMed PMID: 13319493; PubMed Central PMCID: PMC441626.
  • FernandezJL, Perez OM, Effects of gelatin hydrolysates in the prevention of athletic injuries.
    Archivos del medicine del deporte. 1998; 15: 277-282
  • Tsuruoka N, Yamato R, Sakai Y, Yoshitake Y, Yonekura H.Promotion by collagen tripeptide of type I collagen gene expression in human osteoblastic cells and fracture healing of rat femur.
    Biosci Biotechnol Biochem. 2007 Nov;71(11):2680-7.Epub 2007 Nov 7. PubMed PMID: 17986775.
  • Roberts PR, Burney JD, Black KW, Zaloga GP. Effect of chain length on absorption of biologically active peptides from the gastrointestinal tract.
    Digestion. 1999 Jul-Aug;60(4):332-7. PubMed PMID: 10394027.
  • Moskowitz RW, 2000. Role of collagen hydrolysate in bone and joint disease, Semin Arthritis Rheum, 30, 87 - 99
  • Bello AE, Oesser S. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature.
    Curr Med Res Opin. 2006 Nov;22(11):2221-32. Review. PubMed PMID: 17076983.
  • Weh L. Changes in the properties of tissue through the administration of gelatine—a biomechanical in-vivo pilot study.
    Extracta orthopaedica. 2001;4:12-16
  • Oesser S and Seifert J, 2003. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen.
    Cell Tissue Res, 311, 393-399.
  • Oesser S et al., Influence of collagen hydrolysate on the extracellular matrix metabolism of human chondrcytes, Osteoarthritis and Cartilage, 2005, 13 (suppl), 152
  • Oesser S, Seifert J, Impact of collagen fragments on the synthesis and degradation of the extracellular matrix of cartilage tissue, Orthopedic Surgery, 2005, 10, 565- 568, P307
  • Schunck M, Schulze CH, Oesser S, 2009. Collagen peptide supplementation stimulates proteoglycan biosynthesis and aggrecan expression of articular chondrocytes, Osteoarthritis and Cartilage Vol. 17, Suppl.1, 261
  • Oesser S et al., Prophylactic treatment with a special collagen hydrolysate decreases cartilage tissue degeneration in the knee joints , OARSI 2008, Osteoarthritis and Cartilage, 2008, 16 (4), 72
  • Krug E, On supportive therapy for osteo- and chondropathy (in German), Ernährungsheilkunde 1979, 28, 1-23
  • Götz B, Well-nourished cartilage does not grind (in German), Ärztliche Praxis 1982, 34, 3130-3134
  • Oberschelp U, Individual therapy of osteoarthritis is possible (in German), Therapiewoche 1985, 44, 5094-5097
  • Adam M, What effects do gelatine preparations have? Therapy of osteoarthritis (in German), Therapiewoche 1991, 41, 2456-2461
  • Carpenter RL, Peel JB, Carpenter MR, Lowndes J, Angelopoulos TJ, Rippe JM, 2005(b). Effectiveness of a collagen hydrolysate-based supplement on joint pain, range of motion and muscle function in individuals with mild osteoarthritis of the knee: a randomized clinical trial.
    Ann Rheum Dis, 64, 1544
  • Flechsenhar K / Alf D, Results of a post-marketing surveillance study of collagen hydrolysate CH-Alpha (in German), Orthopädische Praxis 9/2005, 486-494 .
  • Clark / Sebastianelli et al.,24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain, Current Medical Research and Opinion, Vol. 24, No. 5, 2008, 1485 – 1496
  • McAlindon TE, Nuite M, Krishnan N, Ruthazer R, Price LL, Burstein D, Griffith J, Flechsenhar K, Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial.
    Osteoarthritis and Cartilage (2011), online 3 January 2011
  • Gelita in-house study (unpublished) In vitro effects of Fortigel Collagen peptides on RNA expression of collagen, elastin and peoteoglycan in tendons and ligaments.
  • Iwai K, Hasegawa T, Taguchi Y, Morimatsu F, Sato K, Nakamura Y, Higashi A, Kido Y, Nakabo Y, Ohtsuki K. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates.
    J Agric Food Chem. 2005 Aug 10;53(16):6531-6. PubMed PMID: 16076145.
  • Sugihara F, Inoue N, Kuwamori M, Taniguchi M. Quantification of hydroxyprolyl-glycine (Hyp-Gly) in human blood after ingestion of collagen hydrolysate.
    Biosci Bioeng. 2012 Feb;113(2):202-3. Epub 2011 Oct 29. PubMed PMID: 22040651.
  • Yasutaka Shigemuraa et all. Identification of a novel food-derived collagen peptide, hydroxyprolyl-glycine, in human peripheral blood by pre-column derivatisation with phenyl isothiocyanate.
    Food Chemistry Volume 129, Issue 3, 1 December 2011, Pages 1019–1024
  • Zague V, de Freitas V, da Costa Rosa M, de Castro GÁ, Jaeger RG, Machado-Santelli GM. Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity.
    J Med Food. 2011 Jun;14(6):618-24. Epub 2011 Apr 11. PubMed PMID: 21480801.
  • Nakatani S, Mano H, Sampei C, Shimizu J, Wada M. Chondroprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage in vitro and in vivo.
    Osteoarthritis Cartilage. 2009 Dec;17(12):1620-7. Epub 2009 Jul 8. PubMed PMID: 19615963
  • Ohara H, Iida H, Ito K, Takeuchi Y, Nomura Y. ffects of Pro-Hyp, a collagen hydrolysate-derived peptide, on hyaluronic acid synthesis using in vitro cultured synovium cells and oral ingestion of collagen hydrolysates in a guinea pig model of osteoarthritis.
    Biosci Biotechnol Biochem. 2010;74(10):2096-9. Epub 2010 Oct 7. PubMed PMID: 20944430.
  • Ohara H, Ichikawa S, Matsumoto H, Akiyama M, Fujimoto N, Kobayashi T, Tajima S. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts.
    J Dermatol. 2010 Apr;37(4):330-8. PubMed PMID: 20507402.
  • Ichikawa S, Morifuji M, Ohara H, Matsumoto H, Takeuchi Y, Sato K. Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate.
    Int J Food Sci Nutr. 2010 Feb;61(1):52-60. PubMed PMID: 19961355.
  • Ohara H, Matsumoto H, Ito K, Iwai K, Sato K. Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources.
    J Agric Food Chem. 2007 Feb 21;55(4):1532-5. Epub 2007 Jan 25. PubMed PMID: 17253720.
  • Samonina G, Ashmarin I, Lyapina L. Glyproline peptide family: review on bioactivity and possible origins. Pathophysiology. 2002 Aug;8(4):229-234. PubMed PMID: 12100966.
  • Chiang TM, Postlethwaite AE, Beachey EH, Seyer JM, Kang AH. Binding of chemotactic collagen-derived peptides to fibroblasts. The relationship to fibroblast chemotaxis. J Clin Invest.
    1978 Nov;62(5):916-22. PubMed PMID: 711857; PubMed Central PMCID: PMC371848.
  • Postlethwaite AE, Seyer JM, Kang AH. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proc Natl Acad Sci U S A. 1978 Feb;75(2):871-5.
    PubMed PMID: 204938; PubMed Central PMCID: PMC411359.
  • Goggs R, Vaughan-Thomas A, Clegg PD, Carter SD, Innes JF, Mobasheri A, Shakibaei M, Schwab W, Bondy CA. Nutraceutical therapies for degenerative joint diseases: a critical review. Crit Rev Food Sci Nutr. 2005;45(3):145-64. Review. PubMed PMID: 16048146.
  • Loeser RF. Age-related changes in the musculoskeletal system and the development of osteoarthritis. Clin Geriatr Med. 2010 Aug;26(3):371-86.
    Review. PubMed PMID: 20699160; PubMed Central PMCID: PMC2920876.
  • Pelletier JP, Martel-Pelletier J. DMOAD developments: present and future. Bull NYU Hosp Jt Dis. 2007;65(3):242-8. Review. PubMed PMID: 17922676.
  • Buckwalter JA. Articular cartilage. Instr Course Lect. 1983;32:349-70. PubMed PMID: 6085932.
  • Wu J, Fujioka M, Sugimoto K, Mu G, Ishimi Y. Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats.
    J Bone Miner Metab. 2004;22(6):547-53. PubMed PMID: 15490264.
  • Trč T, Bohmová J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA).
    Int Orthop. 2011 Mar;35(3):341-8. Epub 2010 Apr 19. PubMed PMID: 20401752; PubMed Central PMCID: PMC3047656.
  • Maruyama S, Nonaka I, Tanaka H. Inhibitory effects of enzymatic hydrolysates of collagen and collagen-related synthetic peptides on fibrinogen/thrombin clotting. Biochim Biophys Acta.
    1993 Jul 10;1164(2):215-8. PubMed PMID: 8329452.
  • Zague V. A new view concerning the effects of collagen hydrolysate intake on skin properties. Arch Dermatol Res. 2008 Oct;300(9):479-83. Epub 2008 Sep 11. PubMed PMID: 18784933.
  • Matsuda N, Koyama Y, Hosaka Y, Ueda H, Watanabe T, Araya T, Irie S, TakehanaK. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J Nutr Sci Vitaminol (Tokyo). 2006 Jun;52(3):211-5. PubMed PMID: 16967766.
  • Verisol human study 1-soon to be published
  • Verisol human study 2- soon to be published
  • van Blitterswijk WJ, van de Nes JC, Wuisman PI.Glucosamine and chondroitin sulfate supplementation to treat symptomatic disc degeneration: biochemical rationale and case report.
    BMC Complement Altern Med. 2003 Jun 10;3:2. Epub 2003 Jun 10. PubMed PMID: 12797867; PubMed Central PMCID: PMC165439.
  • Pelletier JP. Rationale for the use of structure-modifying drugs and agents in the treatment of osteoarthritis. Osteoarthritis Cartilage. 2004;12 Suppl A:S63-8. PubMed PMID: 14698646.
  • Ameye LG, Chee WS. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res Ther. 2006;8(4):R127.
    Review. PubMed PMID: 16859534; PubMed Central PMCID: PMC1779427.
  • Jerosch J. Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids. Int J Rheumatol. 2011;2011:969012.
    Epub 2011 Aug 2. PubMed PMID: 21826146; PubMed Central PMCID: PMC3150191.
  • Aminoacids content ofr foofs and biological data on proteins. FAO Food and Nutrition Series. http://www.fao.org/docrep/005/AC854T/AC854T00.htm
  • Kawaguchi T, Nanbu PN, Kurokawa M. Distribution of prolylhydroxyproline and its metabolites after oral administration in rats. Biol Pharm Bull. 2012;35(3):422-7. PubMed PMID: 22382331.
  • Huang HS, Chang HH. Platelets in inflammation and immune modulations: functions beyond hemostasis. Arch Immunol Ther Exp (Warsz).
    2012 Dec;60(6):443-51. doi: 10.1007/s00005-012-0193-y. Epub 2012 Sep 1. PubMed PMID: 22940877.
  • Zolotarev IuA, Badmaeva KE, Bakaeva ZV, Samonina GE, Kopylova GN, Dadaian AK,Zverkov IuB, Garanin SK, Vas'kovskiĭ BV, Ashmarin IP, Miasoedov NF. [Short peptide fragments with antiulcer activity from a collagen hydrolysate].
    Bioorg Khim. 2006 Mar-Apr;32(2):192-7. Russian. PubMed PMID: 16637291.
  • NHANES (National health and Nutrition Examination Survey) 1994-1996.
  • NHANES (National health and Nutrition Examination Survey) 2001-2002 http://www.ars.usda.gov/Services/docs.htm?docid=13793
  • Poortmans JR, Carpentier A, Pereira-Lancha LO, Lancha A Jr. Protein turnover, amino acid requirements and recommendations for athletes and active populations.
    Braz J Med Biol Res. 2012 Oct;45(10):875-90. Epub 2012 Jun 6. PubMed PMID: 22666780.
  • Fajardo M, Di Cesare PE. Disease-modifying therapies for osteoarthritis :current status. Drugs Aging. 2005;22(2):141-61. Review. PubMed PMID: 15733021.
  • Institute of Medicine of the National Academies. Dietary reference intakes for energy, carbohydrate, fiber, fat, cholesterol, protein, and amino acids. Washington: The National Academies Press; 2005.
  • American College of Sports Medicine ADAaCD. Nutrition and athletic performance. Med Sci Sports Exerc 2009; 709-731.
  • Gelita study (unpublished). NOCA Observational Study conducted in Germany – 2011/2012. Effects of 5g FORTIGEL® on patients with OA of knees and hips.
    Significant reduction of WOMAC scores of pain, stiffness and physical function.
  • B. P. Hughes (1959). The amino-acid composition of three mixed diets. British Journal of Nutrition, 13, pp 330-337 doi:10.1079/BJN19590043
  • Ch. 10 Protein and amino acids. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients) 2005.
    ISBN-10: 0-309-08525-X-08525-0; http://www.nap.edu/openbook.php?record_id=10490&page=589
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    Review. PubMed PMID: 19898232; PubMed Central
  • Houston DK, Nicklas BJ, Ding J, et al. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study.
     Am J Clin Nutr. 2008;87:150–155. [PubMed]
  •  Pepersack T, Corretge M, Beyer I, et al. Examining the effect of intervention to nutritional problems of hospitalised elderly: a pilot project. J Nutr Health Aging. 2002;6:306–310. [PubMed]
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  • Chipponi JX, Bleier JC, Santi MT, Rudman D. 1982. Deficiencies of essential and conditionally essential nutrients. Am J Clin Nutr 35:1112–1116.
  • Harper AE. 1983. Dispensable and indispensable amino acid interrelationships. In:Blackburn GL, Grant JP, Young VR, eds. Amino Acids.
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  • Laidlaw SA, Kopple JD. 1987. Newer concepts of the indispensable amino acids.Am J Clin Nutr 46:593–605.

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Medical Team

Robert Nicolosi, PhD

Robert Nicolosi, PhD, CNS

Chief Science Officer

David M. Brady

David M. Brady, ND, DC, CCN, DACBN

Chief Medical Officer

Jose A. Llobrera

Jose A. Llobrera, PhD

Vice President,
Research and Product Education

Cristiana Paul, MS

Cristiana Paul, MS

Product Development Consultant

Mark Houston

Mark Houston, MD, MS, FACP, FAHA

Medical and Clinical Research Consultant

Robert J. Nicolosi,
PhD, CNS

Chief Science Officer

Dr. Nicolosi is a Professor Emeritus in the Department of Clinical Laboratory and Nutritional Sciences at the University of Massachusetts Lowell, where he also served as Director of the Center for Health and Disease Research. His major research areas include pharmaceutical and nutraceutical interventions for the treatment and prevention of hypercholesterolemia, cardiovascular disease, obesity/diabetes and cancer and micro emulsion technology as it relates to the delivery of nutraceuticals.

David M. Brady,
ND, DC, CCN, DACBN

Chief Medical Officer

Dr. Brady is a licensed Naturopathic Physician, a Chiropractic Physician and a Board Certified Clinical Nutritionist. He is the Vice Provost of the Division of Health Sciences, the Director of the Human Nutrition Institute, and an Associate Professor of Clinical Sciences at the University of Bridgeport in Connecticut. He also serves as the Chief Medical Officer and primary product formulator for Designs for Health, Inc. Dr. Brady is a technical consultant for Metametrix Clinical Laboratories and also maintains a private practice, Whole Body Medicine, in Trumbull, CT, specializing in "Functional and Metabolic Medicine". Finally, Dr. Brady has been the author and contributor for numerous books and professional publications. His newest release is Dr. Brady's Healthy Revolution: What You Really Need to Know to Stay Healthy in a Sick World

Jose A. Llobrera, PhD

Vice President, Research
and Product Education

Dr. Llobrera received his PhD from Texas A&M University and brings with him several years of experience managing research projects. Prior to joining Designs for Health, he spent 5 years in the US nutraceutical industry studying applications of several phytonutrients in cardiovascular health and inflammation.

Cristiana Paul, MS

Product Development Consultant

Cristiana Paul is a nutrition consultant for Designs for Health, serving the Los Angeles area. She holds a Masters in Nutrition Science from Cal Poly Pomona in California, and has 10 years of nutritional counseling experience in clinical practice. Also possessing 10 years of nutrition research experience, Cristiana is relied upon for her contributions to the design and continuous improvement of Designs for Health products.

Mark Houston,
MD, MS, FACP, FAHA

Medical and Clinical Research Consultant

Dr. Houston is Associate Clinical Professor of Medicine at Vanderbilt University School of Medicine and Director of the Hypertension Institute at Saint Thomas Hospital in Nashville, TN. He graduated from Vanderbilt Medical School, completed his Internal Medicine Training at the University of California, San Francisco (UCSF), and served as Chief Resident in Medicine at Vanderbilt University School of Medicine. Dr. Houston is Board Certified in Internal Medicine (ABIM), Hypertension (ASH Specialist in Clinical Hypertension), and Anti-Aging Medicine (ABAAM). He also holds a Masters of Science (MS) degree in Human Nutrition. Having published over 170 medical articles, abstracts, book chapters, and monographs, his recent best-selling books include What Your Doctor May Not Tell You About Hypertension, Handbook of Hypertension for Students and Clinicians, and Vascular Biology for Clinicians. Dr. Houston specializes in hypertension, hyperlipidemia, preventive cardiology, human nutrition, and anti-aging medicine.