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SKU: HTU

5-HTP Supreme™

Mood and Sleep Support*

20 mg of B6 and 100 mg of 5-HTP per serving. Promotes healthy brain function and a positive mood and stress response.* When taken in the evenings, this product may help support healthy sleep quality.*

Synergistic combination of 100 mg of 5-HTP and 20 mg of vitamin B6 (P5P) to support mood health.*

• Supports mood health*
• Promotes a normal response to stress*
• Supports a healthy neurotransmitter balance*
• Promotes optimal brain function*
• Helps support sleep quality and duration*

Recommended Use: Take 1 capsule per day or as directed by your health-care practitioner.

Warning: Not recommended for use by pregnant or lactating women, or by those taking selective serotonin reuptake inhibitor (SSRI) or monoamine oxidase inhibitor (MAOI) medications.

The supreme option for 5-HTP and vitamin B6

5-HTP is a precursor to the neurotransmitters serotonin and melatonin, supporting their synthesis in the body.* Vitamin B6, in its bioavailable form as pyridoxal-5-phosphate (P5P), acts as an essential cofactor for serotonin production and conversion, and may also support the synthesis of other neurotransmitters involved in cognitive function and brain health.* This formula can be taken during the day to support a healthy mood and normal appetite, or at bedtime to promote sleep.* 5-HTP Supreme™ may be used in place of 5-HTP Synergy™ when a higher 5-HTP serving is recommended.*

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.