SKU: HTU

5-HTP Supreme™

Mood and Sleep Support*

20 mg of B6 and 100 mg of 5-HTP per serving. Promotes healthy brain function and a positive mood and stress response.* When taken in the evenings, this product may help support healthy sleep quality.*

Synergistic combination of 100 mg of 5-HTP and 20 mg of vitamin B6 (P5P) to support mood health.*

• Supports mood health*
• Promotes a normal response to stress*
• Supports a healthy neurotransmitter balance*
• Promotes optimal brain function*
• Helps support sleep quality and duration*

Recommended Use: Take 1 capsule per day or as directed by your health-care practitioner.

Warning: Not recommended for use by pregnant or lactating women, or by those taking selective serotonin reuptake inhibitor (SSRI) or monoamine oxidase inhibitor (MAOI) medications.

The supreme option for 5-HTP and vitamin B6

5-HTP is a precursor to the neurotransmitters serotonin and melatonin, supporting their synthesis in the body.* Vitamin B6, in its bioavailable form as pyridoxal-5-phosphate (P5P), acts as an essential cofactor for serotonin production and conversion, and may also support the synthesis of other neurotransmitters involved in cognitive function and brain health.* This formula can be taken during the day to support a healthy mood and normal appetite, or at bedtime to promote sleep.* 5-HTP Supreme™ may be used in place of 5-HTP Synergy™ when a higher 5-HTP serving is recommended.*

5-HTP Supreme™

High-Potency 100 mg 5-HTP and P5P Formula for Mood Health, Stress Response, Neurotransmitter Metabolism, and Sleep Quality*

Key Performance Benefits*

  • Supports mood health
  • Promotes a normal response to stress
  • Supports healthy neurotransmitter metabolism
  • Supports brain function
  • Helps support sleep quality and duration

What This Product Is

5-HTP Supreme provides 100 mg of 5-HTP and 20 mg of P5P (bioactive vitamin B6) to support mood health, a normal response to stress, neurotransmitter balance, and optimal brain function.*

5-HTP is a precursor to serotonin and melatonin. P5P is essential for serotonin production. Serotonin is critical for the gut-brain axis, gastrointestinal health, and sleep quality.*

Mechanism of Action

5-HTP as a Serotonin and Melatonin Precursor

100 mg 5-HTP provides a higher-serving direct precursor to serotonin and melatonin for robust neurotransmitter balance.*

P5P for Serotonin Conversion

20 mg P5P is essential for the enzymatic conversion of 5-HTP to serotonin and supports neurotransmitter synthesis for cognitive function.*

Gut-Brain Axis and Sleep Support

Supports serotonin synthesis for gastrointestinal health via the gut-brain axis. Serotonin precursor to melatonin for sleep quality.*

Applications

  • Individuals seeking higher-potency mood and stress response support*
  • Those looking for neurotransmitter balance through serotonin precursors*
  • Individuals wanting brain function and cognitive support*
  • Those seeking sleep quality support*
  • Individuals preferring a higher amount of 5-HTP (100 mg)

Key Ingredients / Formula Highlights

5-HTP (100 mg) and Vitamin B6 as P5P (20 mg)

Higher-potency synergistic combination. Gluten-free, dairy-free, soy-free, and non-GMO.

Suggested Use

Take 1 capsule per day. Warning: Not for pregnant/lactating or those taking SSRI/MAOI medications.

Product Questions

How does 5-HTP Supreme compare to 5-HTP Synergy?

5-HTP Supreme: 100 mg 5-HTP + 20 mg P5P. 5-HTP Synergy: 50 mg 5-HTP + 10 mg P5P. Same approach, different potency.

Who may benefit most from 5-HTP Supreme?

Individuals seeking higher-potency serotonin precursor support for mood, stress response, brain function, and sleep quality.*

Warning: Not recommended for use by pregnant or lactating women, or by those taking selective serotonin reuptake inhibitor (SSRI) or monoamine oxidase inhibitor (MAOI) medications.

Practitioner Reference

5-HTP Supreme™ is positioned within the Designs for Health Stress/Mood category. Available as HTU060 (60 capsules).

Designs for Health

Terms & Conditions

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.