SKU: ANT15

Annatto-E® 150

150 mg of Delta- and Gamma-Tocotrienols per Serving

Promotes optimal vitamin E status with the preferred form of vitamin E as tocotrienols.* May support cardiovascular, skin, eye, bone, and lung health and antioxidant status.*

Sourced from annatto, the richest known source of naturally occurring vitamin E tocotrienols.

• Supports vitamin E status*
• Promotes metabolic and cardiovascular health*
• Supports antioxidant status and a healthy inflammatory response*
• Supports lung, skin, and eye health*
• Supports healthy bones*

Recommended Use: Take 1 softgel per day or as directed by your health-care practitioner.

Annatto-E® is made with DeltaGold®, containing 100% tocotrienols and 0% tocopherols

Our formula contains the two most bioactive forms of vitamin E tocotrienols (gamma and delta), shown to provide superior support for cardiovascular, liver, and cellular health compared to other vitamin E compounds.* Most conventional supplements are typically rich in tocopherols (alpha‑tocopherol, in particular). However, the tocotrienol forms of vitamin E have beneficial effects across various body systems that allow them to uniquely support overall wellness.* Owing to these benefits, Annatto‑E® may be clinically relevant to the general population.*

Annatto-E® is a tocotrienol-only vitamin E supplement by Designs for Health, delivering 150 mg or 300 mg of delta- and gamma-tocotrienols per serving, which are forms of vitamin E, per softgel.* Sourced from annatto seeds — the richest known natural source of tocotrienols — it provides 100% tocotrienols and 0% tocopherols for targeted metabolic and antioxidant support.*

Annatto-E® is formulated to support cardiovascular and metabolic health through its concentrated delta- and gamma-tocotrienol content.* Tocotrienols are forms of vitamin E that promote healthy cholesterol metabolism and antioxidant status.* Individual results may vary based on diet, lifestyle, and overall health status.*

Key benefits include support for vitamin E status, metabolic and cardiovascular health, antioxidant status, and bone, skin, eye, and lung health.* These benefits are unique to the tocotrienol forms of vitamin E, which have distinct properties not found in common tocopherol-based supplements, which use another form of vitamin E.*

Take one softgel per day, or as directed by your healthcare practitioner. For optimal results, take tocotrienols at least 6 hours apart from supplements containing alpha-tocopherols, another form of vitamin E, as tocopherols may interfere with tocotrienol benefits.* Available in 150 mg and 300 mg serving sizes.

Annatto-E® contains DeltaGold® delta- and gamma-tocotrienols, which are forms of vitamin E, sourced exclusively from annatto seeds.* These tocotrienol forms of vitamin E support antioxidant status, cardiovascular function, healthy lipid metabolism, bone health, and skin wellness — with properties distinct from conventional tocopherol-based vitamin E supplements.*

You may notice support for overall metabolic wellness, antioxidant status, and cardiovascular health with consistent use.* Tocotrienols are forms of vitamin E, and benefits typically develop over several weeks of daily supplementation.* Results depend on baseline vitamin E status, diet, lifestyle, and healthcare practitioner guidance.*

Annatto-E® is designed for daily use when taken as directed.* It is gluten-free, dairy-free, soy-free, and non-GMO.* Consult your healthcare practitioner before use if you are pregnant, nursing, taking medications, or managing a health condition.*

Annatto-E® contains 100% tocotrienols, which are forms of vitamin E, and 0% tocopherols, another form of vitamin E — the opposite of most commercial vitamin E supplements.* Sourced from annatto seeds (the richest natural tocotrienol source), it provides the delta and gamma forms that research suggests have unique cardiovascular and metabolic benefits not shared by alpha-tocopherol, another form of vitamin E.*

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.