SKU: ANT

Annatto-E® Synergy

Delta- and Gamma-Tocotrienols and Black Cumin Seed Oil

Vitamin E tocotrienols plus black cumin seed oil acts as a synergistic blend to promote healthy inflammatory responses, lipid metabolism, and antioxidant status.*

A unique tocopherol-free, tocotrienols-only product containing 125 mg tocotrienols along with 1 g black cumin seed oil (Nigella sativa) per 2-softgel serving.

•Promotes cardiovascular health*
• Supports metabolic health*
• Supports liver health*
• Supports antioxidant status*
• Supports healthy inflammatory responses*
• May help support respiratory and bone health*

Recommended Use: Take 2 softgels per day or as directed by your health-care practitioner.

Vitamin E and black cumin seed oil promotes heart health and antioxidant status*

Our formula combines black cumin seed oil with the two most bioactive forms of vitamin E tocotrienols (gamma and delta). These forms of vitamin E are shown to provide superior support for heart, liver, and cellular health compared to other vitamin E compounds.* Most conventional supplements are typically rich in tocopherols (alpha‑tocopherol, in particular). However, the tocotrienol forms of vitamin E have beneficial effects across various body systems that allow them to uniquely support overall wellness.*

Annatto-E® Synergy is a combination formula by Designs for Health that pairs DeltaGold® tocotrienols (the preferred form of vitamin E) with black cumin seed.* This synergistic blend supports cardiovascular health, metabolic function, antioxidant status, immune balance, brain health, and respiratory wellness.*

Annatto-E® Synergy is formulated to support immune balance, metabolic health, and antioxidant status through its combination of tocotrienols, which are forms of vitamin E, and thymoquinone from black cumin seed.* The synergistic pairing promotes full-body support.* Individual results may vary based on diet, lifestyle, and overall health status.*

Key benefits include support for cardiovascular health, metabolic function, antioxidant status, balanced immune responses, brain health, and respiratory wellness.* These benefits are supported by the synergistic combination of annatto-derived tocotrienols and the active compound thymoquinone from black cumin seed.*

Take two softgels per day, or as directed by your healthcare practitioner. For best results, use consistently as part of your daily wellness routine.* Consider spacing intake at least 6 hours from supplements containing alpha-tocopherols to optimize tocotrienol benefits.*

Annatto-E® Synergy contains DeltaGold® delta- and gamma-tocotrienols, which are forms of vitamin E, from annatto seeds for antioxidant status and metabolic support.* It also includes black cumin seed, whose active compound thymoquinone promotes immune system balance and supports respiratory and bone health.*

You may notice support for metabolic wellness, immune resilience, and overall vitality with regular use.* The synergistic pairing of tocotrienols and black cumin seed promotes multiple body systems.* Results depend on baseline health, diet, lifestyle habits, and healthcare practitioner guidance.*

Annatto-E® Synergy is designed for daily use when taken as directed.* It features naturally derived ingredients from annatto seeds and black cumin seed.* Consult your healthcare practitioner before use if you are pregnant, nursing, taking medications, or managing a health condition.*

Annatto-E® Synergy builds upon standard Annatto-E® by adding black cumin seed with its active compound thymoquinone.* This combination expands the formula's scope to include additional immune, respiratory, and bone health support beyond what tocotrienols alone provide — offering a more comprehensive full-body formula.*

Designs for Health

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.