SKU: BSP

B-Supreme

Bioactive B Vitamin Complex

A potent B vitamin complex formulated with bioidentical and coenzymated forms of B vitamins for enhanced nutrient absorption and bioavailability.

Features folate, as Quatrefolic® 5-methyltetrahydrofolate (5-MTHF), and vitamin B12, as methylcobalamin — the body’s preferred forms of these vitamins.

• Supports B vitamin status in the body*
• Promotes the optimal intake of essential micronutrients for overall health*
• Supports cardiovascular and metabolic health*
• May be helpful for individuals following a vegan or vegetarian diets, or those with insufficient dietary B vitamin intake*

Recommended Use: Take 1 capsule per day with a meal or as directed by your health-care practitioner.

Choline and trimethylglycine (TMG) for extra support*

Choline is a vitamin-like, essential nutrient that is similar in structure to other B vitamins and must be consumed in the diet to maintain optimal health. It is an essential structural component of all cell membranes, which is involved in many bodily processes, including normal metabolism, methylation, and neurotransmitter production. TMG, also known as betaine, is also an important cofactor in methylation, which is a process that occurs in all cells, and is required for cardiovascular and cognitive health.*

B-Supreme is a comprehensive B vitamin complex by Designs for Health that delivers all eight essential B vitamins in the body's preferred, pre-activated coenzymated forms.* It features methylated folate (as Quatrefolic®) and methylcobalamin (as MecobalActive®), plus choline and trimethylglycine (TMG) to support methylation and cellular health.*

B-Supreme is formulated to support healthy energy production and normal methylation through bioactive B vitamins, choline, and trimethylglycine (TMG).* B vitamins are essential for one-carbon metabolic reactions that support homocysteine metabolism.* Individual results may vary based on diet, genetic factors, and overall health status.*

Key benefits include support for B vitamin status, cardiovascular and metabolic health, energy production, and healthy methylation pathways.* These benefits are driven by coenzymated B vitamin forms, methylated folate and B12, plus choline and TMG for comprehensive methylation support.*

Take one capsule per day with a meal, or as directed by your healthcare practitioner. B vitamins are water-soluble and cannot be stored in the body, making consistent daily intake important. B-Supreme is delivered in a vegetable capsule suitable for vegetarians and vegans.

B-Supreme contains all eight essential B vitamins in coenzymated forms, including Quatrefolic® 5-MTHF folate and MecobalActive® methylcobalamin for superior bioavailability.* It also includes choline and trimethylglycine (TMG) to support methylation pathways, DNA function, and healthy homocysteine metabolism.*

You may notice support for energy production, mental clarity, and overall vitality with regular use.* B vitamins are water-soluble and must be replenished daily for optimal function.* Results are influenced by dietary intake, genetic methylation factors such as MTHFR variations, which can affect how the body uses certain B vitamins, stress levels, and practitioner guidance.*

B-Supreme is designed for daily use when taken as directed.* Its coenzymated and methylated forms are well-tolerated and readily utilized by the body.* Consult your healthcare practitioner before use if you are pregnant, nursing, taking medications, or managing a health condition.*

B-Supreme stands apart by using coenzymated, bioidentical forms of all eight B vitamins — including methylated folate and B12 — rather than synthetic forms found in many standard formulas.* The addition of choline and TMG provides targeted methylation support not typically found in conventional B complex supplements.*

Designs for Health

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.