SKU: CAC

CatecholaCalm™

Stress and Relaxation Support*

Curated blend of botanicals and nutrients to promote a healthy stress response, normal neurotransmitter production, and healthy adrenal gland function.*

A comprehensive formula with standardized lemon balm, passionflower, valerian root, and ashwagandha extracts, methylated B vitamins, L-theanine, and phosphatidylserine.

• Promotes a healthy stress response*
• Supports normal neurotransmitter synthesis*
• Supports healthy adrenal gland function*
• Supports normal GABA activity for mental calm*
• May help support balanced moods and promote calmness and relaxation*

Recommended Use: Take 3 capsules per day or as directed by your
health-care practitioner.

Adaptogenic and adrenal tonic herbs

Ashwagandha is an adaptogenic herb with a long history in Ayurvedic medicine, helping support a healthy stress response.* Valerian, lemon balm, and passionflower are herbs that promote relaxation, in part by supporting the production of gamma-aminobutyric acid (GABA) to help balance the stress hormones.*

CatecholaCalm™ is an adrenal support supplement from Designs for Health formulated for individuals who feel “wired and tired” — simultaneously overstimulated and mentally or physically exhausted.* This pattern is associated with adrenocortical exhaustion or “burnout,” where ongoing stress is linked to increased sympathetic (catecholamine) activity, making it important to address both cortisol and catecholamine balance.* The formula combines adaptogenic, nervine, and adrenal tonic herbs with targeted nutrients to support the body’s stress-response system and healthy adrenal function.*

It is designed to support healthy catecholamine and cortisol metabolism while promoting calm and relaxation without drowsiness.* It also supports GABA activity for mental calm, along with a healthy stress response and normal neurotransmitter synthesis.*

CatecholaCalm™ from Designs for Health is formulated to support a balanced stress response by helping regulate cortisol and catecholamines such as adrenaline and norepinephrine, the primary stress hormones produced by the adrenal glands.* It may be especially beneficial for individuals who feel “wired and tired,” meaning mentally overstimulated yet physically exhausted from ongoing stress.*

The formula combines adaptogenic herbs with targeted nutrients to support GABA activity, neurotransmitter balance, and healthy adrenal function.* Together, these ingredients help promote calm and relaxation without drowsiness, support a healthy stress response, and promote a positive mental outlook and emotional well-being.* Individual results may vary depending on stress levels, diet, physical activity, and overall lifestyle.*

CatecholaCalm™ from Designs for Health is designed to support a healthy stress response by helping the body manage occasional stress through balanced cortisol and catecholamine metabolism, which influence energy production, mood, and overall well-being.* It also supports healthy adrenal gland function, which is involved in the production of the body’s primary stress hormones.*

In addition, CatecholaCalm™ supports normal neurotransmitter production, including GABA activity, promoting mental calmness and relaxation without drowsiness and making it suitable for daytime use.*

Taking CatecholaCalm™ is simple. The recommended use is 3 capsules per day, or as directed by your health-care practitioner.

For personalized guidance on how CatecholaCalm™ fits into your overall wellness plan, consult with your health-care practitioner about your specific circumstances and any questions you may have.*

CatecholaCalm™ from Designs for Health combines adaptogenic herbs, calming botanicals, and targeted nutrients to help the body manage occasional stress and promote relaxation without drowsiness.* Ashwagandha supports healthy cortisol metabolism and a balanced stress response, while valerian root, lemon balm, and passionflower promote calmness through GABA-related pathways.* L-theanine, taurine, and phosphatidylserine support relaxation, neurotransmitter balance, and healthy stress-response function.* The formula also includes vitamin C, methylated B vitamins, and magnesium to support adrenal function and stress hormone metabolism.* Together, these ingredients support a calm mood, balanced cortisol and catecholamine metabolism, and a relaxed state of mind.*

With consistent use, you may notice support for calmness and relaxation, a healthier response to occasional stress, and more balanced moods.* CatecholaCalm™ supports both the hormonal and neurotransmitter aspects of the stress response by helping maintain healthy cortisol and catecholamine (adrenaline) balance.* Individual results may vary depending on factors such as stress levels, sleep quality, diet, physical activity, and overall lifestyle, all of which influence how the adrenal glands and nervous system respond to stress.* Consult your health-care practitioner for personalized guidance.*

CatecholaCalm™ is designed for daily use when taken as directed, with a recommended serving of 3 capsules per day or as advised by your healthcare practitioner.* It is gluten-free, dairy-free, soy-free, vegan, and non-GMO, making it suitable for a wide range of dietary needs.* The formula features standardized botanical extracts, including ashwagandha, lemon balm, passionflower, and valerian root, along with methylated B vitamins.* Consult your healthcare practitioner before use if you are pregnant, nursing, taking medications, or managing a health condition.*

Both CatecholaCalm™ and Adrenotone™ are designed to support adrenal health and a healthy stress response,* but they work in different ways.*

CatecholaCalm™ focuses on calming the nervous system, featuring botanicals such as lemon balm, passionflower, and ashwagandha, along with L-theanine, to promote relaxation and support healthy neurotransmitter balance.*

Adrenotone™ takes a more restorative approach, combining adaptogenic herbs with B vitamins and N-Acetyl L-Tyrosine to help nourish the adrenal glands and support healthy cortisol and energy metabolism.*

Your healthcare practitioner can recommend the best option based on your stress response pattern.*

Designs for Health

Terms & Conditions

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

©2019-2026 Designs for Health, Inc. All rights reserved.

The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.