SKU: DIM

DIM-Evail™

Healthy Estrogen Metabolism*

Features DIM, a compound found naturally in cruciferous vegetables, to support healthy estrogen metabolism and healthy inflammatory responses.*

100 mg of diindolylmethane per serving, formulated with Evail™ technology to optimize bioavailability and absorption.

• Supports healthy estrogen balance*
• Promotes a healthy 2:16 hydroxyestrone ratio*
• Promotes a healthy inflammatory response*

Recommended Use: Take 1 softgel per day with a meal or as directed by your
health-care practitioner.

Enhanced absorption

DIM-Evail™ is manufactured using Designs for Health’s proprietary Evail™ emulsification technology, which is designed to enhance the bioavailability and absorption of bioactive ingredients. This Evail™ process uses an extract derived from the quillaja plant, vitamin E, delta- and gamma-tocotrienols, and medium-chain triglycerides (MCTs) to support absorption.

DIM-Evail™

Diindolylmethane (DIM) with Evail™ Emulsification Technology for Healthy Estrogen Metabolism and Inflammatory Response Support*

Key Performance Benefits*

  • Supports healthy estrogen balance
  • Promotes healthy inflammatory response

What This Product Is

DIM-Evail™ provides 100 mg of diindolylmethane (DIM), a compound classified as a plant indole. Plant indoles, also called glucosinolates, are found in cruciferous vegetables such as broccoli, cabbage, and cauliflower. They are among the nutrients responsible for the widely recognized healthful properties of these foods, including the support of a healthy estrogen balance and inflammatory response.*

The primary plant indole in cruciferous vegetables is indole-3-carbinol (I3C), which converts to DIM in the body. Supplemental DIM may provide the noted health effects without producing the unwanted side effects of supplemental I3C, such as possible nausea and equilibrium issues. Both I3C and DIM have been studied for their health-promoting benefits including the support of healthy estrogen metabolism.* DIM-Evail™ is manufactured using the proprietary Evail™ emulsification technology with quillaja extract, vitamin E, delta- and gamma-tocotrienols, and medium-chain triglycerides (MCTs) to enhance bioavailability and absorption.

Mechanism of Action

Estrogen Metabolism Support*

DIM supports healthy estrogen metabolism by promoting favorable pathways of estrogen breakdown in the body. This helps maintain a healthy estrogen balance, which is important for both men and women as part of overall endocrine health.*

Inflammatory Response Modulation*

As a plant indole derived from cruciferous vegetables, DIM promotes a healthy inflammatory response. The glucosinolates found in cruciferous vegetables have been extensively studied for their broad health-promoting properties.*

Evail™ Enhanced Bioavailability

The Evail™ emulsification technology uses quillaja extract, vitamin E, delta- and gamma-tocotrienols, and MCTs to enhance the bioavailability and absorption of DIM, ensuring efficient delivery and utilization of this plant indole.

Athletic Applications

  • Individuals seeking to support healthy estrogen metabolism and balance*
  • Those looking for plant indole support from cruciferous vegetable compounds*
  • Individuals seeking a healthy inflammatory response*
  • Those who prefer DIM over I3C supplementation to avoid potential side effects
  • Individuals seeking enhanced bioavailability of DIM through Evail™ technology

Key Ingredients / Formula Highlights

Diindolylmethane / DIM (100 mg per serving)

A plant indole from cruciferous vegetables that supports healthy estrogen metabolism and balance. DIM provides the benefits of cruciferous vegetable compounds without the potential side effects associated with supplemental I3C.*

Evail™ Emulsification Technology

Proprietary technology using quillaja extract, vitamin E, delta- and gamma-tocotrienols (as DeltaGold®), and MCTs to optimize bioavailability and absorption. Gluten-free, dairy-free, and non-GMO.

Suggested Use

Take 1 softgel per day with a meal, or as directed by your health-care practitioner.

Frequently Asked Questions

What is the difference between DIM and I3C?

Indole-3-carbinol (I3C) is the primary plant indole in cruciferous vegetables, which converts to DIM in the body. Supplemental DIM provides the health benefits directly without the potential unwanted side effects of supplemental I3C, such as nausea and equilibrium issues.* DIM-Evail™ provides DIM in an enhanced bioavailability format for efficient absorption.

How does DIM-Evail™ relate to FemGuard Balance?

DIM-Evail™ provides focused DIM support for healthy estrogen metabolism using Evail™ technology for enhanced absorption. FemGuard Balance is a broader formula that addresses multiple aspects of female hormone health. DIM-Evail™ may be preferred when targeted estrogen metabolism support is the primary goal, and it can be used by both men and women.*

Who may benefit most from DIM-Evail™?

Individuals seeking to support healthy estrogen metabolism and balance, those looking for the health benefits of cruciferous vegetable compounds in a convenient supplemental form, and anyone seeking a healthy inflammatory response through plant indole supplementation.*

Practitioner Reference

DIM-Evail™ is positioned within the Designs for Health Endocrine/Metabolism category. Available as DIM060 (60 softgels) and DIM120 (120 softgels). DeltaGold® is a registered trademark of American River Nutrition, LLC. This product is intended for use under the guidance of a licensed health-care practitioner.

Designs for Health

Terms & Conditions

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.