SKU: DIM

DIM-Evail™

Healthy Estrogen Metabolism*

Features DIM, a compound found naturally in cruciferous vegetables, to support healthy estrogen metabolism and healthy inflammatory responses.*

100 mg of diindolylmethane per serving, formulated with Evail™ technology to optimize bioavailability and absorption.

• Supports healthy estrogen balance*
• Promotes a healthy 2:16 hydroxyestrone ratio*
• Promotes a healthy inflammatory response*

Recommended Use: Take 1 softgel per day with a meal or as directed by your
health-care practitioner.

Enhanced absorption

DIM-Evail™ is manufactured using Designs for Health’s proprietary Evail™ emulsification technology, which is designed to enhance the bioavailability and absorption of bioactive ingredients. This Evail™ process uses an extract derived from the quillaja plant, vitamin E, delta- and gamma-tocotrienols, and medium-chain triglycerides (MCTs) to support absorption.

DIM-Evail™ is a hormone-supportive supplement by Designs for Health that delivers 100 mg of diindolylmethane (DIM) per softgel.* It supports healthy estrogen balance and a healthy inflammatory response.*

What makes DIM-Evail™ unique is its proprietary Evail™ technology — a special delivery system designed to help your body absorb DIM more effectively.*

DIM-Evail™ is formulated to support healthy estrogen balance.* It delivers 100 mg of diindolylmethane (DIM) per softgel. DIM is derived from indole-3-carbinol (I3C), which is a plant compound found in cruciferous vegetables such as broccoli, cabbage, and cauliflower. The body converts I3C into DIM in the body to promote beneficial estrogen metabolites that support healthy estrogen balance.* It also supports a healthy inflammatory response.*

DIM-Evail™ uses Designs for Health’s proprietary Evail™ technology, a delivery system designed to enhance DIM absorption.* Take 1 softgel per day with a meal or as directed by your healthcare practitioner. Individual results may vary based on hormonal status and lifestyle.*

What are the key benefits of DIM-Evail™?Key benefits of DIM-Evail™ include support for healthy estrogen balance and a healthy inflammatory response.* These benefits are supported by 100 mg of DIM per serving, supported by Evail™ technology, a special delivery system using quillaja extract, MCTs, and tocotrienols designed to improve absorption.* This delivers the health benefits of cruciferous vegetables in a concentrated form that your body can absorb.*

Take 1 softgel per day with a meal, or as directed by your healthcare practitioner.* DIM-Evail™ is formulated with proprietary Evail™ technology — a special delivery system designed to help your body absorb DIM more effectively.* For best results, take it consistently each day as part of your daily routine.* Consult your healthcare practitioner about your specific circumstances and any questions you may have about this product.*

DIM-Evail™ contains two key components: the active ingredient DIM and the Evail™ delivery system, designed to enhance DIM absorption.* DIM (Diindolylmethane), provided at 100 mg per serving, supports healthy estrogen balance by promoting beneficial estrogen breakdown products as well as a healthy inflammatory response.*

The Evail™ delivery system combines quillaja extract, DeltaGold® tocotrienols, and medium-chain triglycerides (MCTs) to support absorption of DIM.* Quillaja extract from the bark of the Quillaja saponaria tree helps support nutrient absorption, DeltaGold® tocotrienols are forms of vitamin E that promote antioxidant status and support cellular resilience, and MCTs are easily digested fats that further support ingredient absorption.* Together, these components enhance DIM uptake and bioavailability.*

DIM-Evail™ is formulated to support healthy estrogen balance and a healthy inflammatory response.* DIM helps promote beneficial estrogen breakdown products that contribute to healthy estrogen balance.*

Because hormonal health is unique to each individual, results may vary based on factors such as hormone status, diet, lifestyle, and practitioner guidance.* Eating cruciferous vegetables such as broccoli, cabbage, and cauliflower also supports overall hormonal health.* For best results, take DIM-Evail™ consistently as directed and consult your healthcare practitioner about your individual needs.*

DIM-Evail™ is designed for daily use when taken as directed — simply take 1 softgel per day with a meal.* It uses Evail™ technology, a special delivery system that helps your body absorb and use DIM effectively,* and is made without harsh additives.* Consult your healthcare practitioner before use if you are pregnant, nursing, taking hormonal medications, or managing a health condition.*

DIM-Evail™ delivers a concentrated 100 mg of DIM per softgel, along with Evail™ technology — a special delivery system designed to help your body take in and use DIM effectively.* Cruciferous vegetables like broccoli, cabbage, and cauliflower are a natural source of indole-3-carbinol (I3C), which is converted into DIM in the body. However, maintaining a healthy DIM status from dietary sources alone can be difficult.* DIM-Evail™ offers a convenient way to get a reliable daily amount of DIM in a form your body can readily absorb and use,* without relying solely on dietary intake of cruciferous vegetables.

DIM-Evail™

Diindolylmethane (DIM) with Evail™ Emulsification Technology for Healthy Estrogen Metabolism and Inflammatory Response Support*

Key Performance Benefits*

  • Supports healthy estrogen balance
  • Promotes healthy inflammatory response

What This Product Is

DIM-Evail™ provides 100 mg of diindolylmethane (DIM), a compound classified as a plant indole. Plant indoles, also called glucosinolates, are found in cruciferous vegetables such as broccoli, cabbage, and cauliflower. They are among the nutrients responsible for the widely recognized healthful properties of these foods, including the support of a healthy estrogen balance and inflammatory response.*

The primary plant indole in cruciferous vegetables is indole-3-carbinol (I3C), which converts to DIM in the body. Supplemental DIM may provide the noted health effects without producing the unwanted side effects of supplemental I3C, such as possible nausea and equilibrium issues. Both I3C and DIM have been studied for their health-promoting benefits including the support of healthy estrogen metabolism.* DIM-Evail™ is manufactured using the proprietary Evail™ emulsification technology with quillaja extract, vitamin E, delta- and gamma-tocotrienols, and medium-chain triglycerides (MCTs) to enhance bioavailability and absorption.

Mechanism of Action

Estrogen Metabolism Support*

DIM supports healthy estrogen metabolism by promoting favorable pathways of estrogen breakdown in the body. This helps maintain a healthy estrogen balance, which is important for both men and women as part of overall endocrine health.*

Inflammatory Response Modulation*

As a plant indole derived from cruciferous vegetables, DIM promotes a healthy inflammatory response. The glucosinolates found in cruciferous vegetables have been extensively studied for their broad health-promoting properties.*

Evail™ Enhanced Bioavailability

The Evail™ emulsification technology uses quillaja extract, vitamin E, delta- and gamma-tocotrienols, and MCTs to enhance the bioavailability and absorption of DIM, ensuring efficient delivery and utilization of this plant indole.

Applications

  • Individuals seeking to support healthy estrogen metabolism and balance*
  • Those looking for plant indole support from cruciferous vegetable compounds*
  • Individuals seeking a healthy inflammatory response*
  • Those who prefer DIM over I3C supplementation to avoid potential side effects
  • Individuals seeking enhanced bioavailability of DIM through Evail™ technology

Key Ingredients / Formula Highlights

Diindolylmethane / DIM (100 mg per serving)

A plant indole from cruciferous vegetables that supports healthy estrogen metabolism and balance. DIM provides the benefits of cruciferous vegetable compounds without the potential side effects associated with supplemental I3C.*

Evail™ Emulsification Technology

Proprietary technology using quillaja extract, vitamin E, delta- and gamma-tocotrienols (as DeltaGold®), and MCTs to optimize bioavailability and absorption. Gluten-free, dairy-free, and non-GMO.

Suggested Use

Take 1 softgel per day with a meal, or as directed by your health-care practitioner.

Product Questions

What is the difference between DIM and I3C?

Indole-3-carbinol (I3C) is the primary plant indole in cruciferous vegetables, which converts to DIM in the body. Supplemental DIM provides the health benefits directly without the potential unwanted side effects of supplemental I3C, such as nausea and equilibrium issues.* DIM-Evail™ provides DIM in an enhanced bioavailability format for efficient absorption.

How does DIM-Evail™ relate to FemGuard Balance?

DIM-Evail™ provides focused DIM support for healthy estrogen metabolism using Evail™ technology for enhanced absorption. FemGuard Balance is a broader formula that addresses multiple aspects of female hormone health. DIM-Evail™ may be preferred when targeted estrogen metabolism support is the primary goal, and it can be used by both men and women.*

Who may benefit most from DIM-Evail™?

Individuals seeking to support healthy estrogen metabolism and balance, those looking for the health benefits of cruciferous vegetable compounds in a convenient supplemental form, and anyone seeking a healthy inflammatory response through plant indole supplementation.*

Practitioner Reference

DIM-Evail™ is positioned within the Designs for Health Endocrine/Metabolism category. Available as DIM060 (60 softgels) and DIM120 (120 softgels). DeltaGold® is a registered trademark of American River Nutrition, LLC. This product is intended for use under the guidance of a licensed health-care practitioner.

Designs for Health

Terms & Conditions

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.