SKU: HGD

HistaGest-DAO™

Dietary Histamine Metabolism Support*

20,000 histamine‐degrading units of diamine oxidase (DAO) to support those with sensitivities to histamine-rich foods.*

DAO is the digestive enzyme responsible for breaking down food‑derived histamine, to help support normal and healthy histamine metabolism.*

• Promotes normal histamine metabolism*
• Promotes the breakdown of food‑derived histamines*
• Enhances DAO activity in the gastrointestinal (GI) tract*
• May support individuals who are intolerant to histamine‑rich foods*

Recommended Use: Take 1 tablet just prior to the consumption of histamine-rich foods or as directed by your health-care practitioner. (Take by mouth and swallow whole 20 minutes before meals.)

Supports the digestion of histamine-containing foods* – available in a travel-friendly dispenser

HistaGest‑DAO™ is formulated with gastro‑resistant coated tablets with delayed‑release technology, allowing the DAO enzyme to reach the small intestine and perform its beneficial action. Taking 1 tablet before each meal helps promote the amount of DAO in the small bowel to help break down histamine in the digestive tract supporting digestive comfort for individuals with sensitivity to histamine‑rich foods.*

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.