SKU: HYS

Homocysteine Supreme™

Methylation and Cardiovascular Support*

Designed to promote cardiovascular health and cognitive function by supporting healthy homocysteine metabolism and normal methylation.*

Bioactive forms of vitamin B2, vitamin B6, folate (as 5-MTHF), and vitamin B12 to support proper homocysteine metabolism.*

• Supports healthy homocysteine metabolism*
• Supports normal methylation status*
• Supports cardiovascular health*
• Supports brain and cognitive health*

Recommended Use: Take 2 capsules per day with meals or as directed by
your health-care practitioner.

May help promote healthy homocysteine metabolism*

An optimally functioning homocysteine pathway supplies key methyl and sulfur groups needed for overall health and critical biochemical processes, such as detoxification, immune support, cognitive and reproductive function, and cardiovascular health.* This pathway requires the vitamins B2, B6, folate, and B12. Trimethylglycine (betaine) and serine work alongside the B vitamins to support healthy methylation.*

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Designs for Health

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.