SKU: HYS

Homocysteine Supreme™

Methylation and Cardiovascular Support*

Designed to promote cardiovascular health and cognitive function by supporting healthy homocysteine metabolism and normal methylation.*

Bioactive forms of vitamin B2, vitamin B6, folate (as 5-MTHF), and vitamin B12 to support proper homocysteine metabolism.*

• Supports healthy homocysteine metabolism*
• Supports normal methylation status*
• Supports cardiovascular health*
• Supports brain and cognitive health*

Recommended Use: Take 2 capsules per day with meals or as directed by
your health-care practitioner.

May help promote healthy homocysteine metabolism*

An optimally functioning homocysteine pathway supplies key methyl and sulfur groups needed for overall health and critical biochemical processes, such as detoxification, immune support, cognitive and reproductive function, and cardiovascular health.* This pathway requires the vitamins B2, B6, folate, and B12. Trimethylglycine (betaine) and serine work alongside the B vitamins to support healthy methylation.*

Homocysteine Supreme™ is formulated to promote healthy homocysteine metabolism.* This formula delivers a targeted blend of bioactive B vitamins — including B2, B6, folate (as Quatrefolic®), and B12 (as MecobalActive®) — plus Trimethylglycine (TMG).* These nutrients work together to support your body's methylation process, which helps convert homocysteine into other beneficial compounds.* Together, they provide focused support for heart health, normal brain function, and healthy methylation.*

Homocysteine Supreme™ is formulated to support healthy homocysteine metabolism, a natural process involved in breaking down and processing homocysteine in the body.* It provides a blend of bioactive B vitamins and Trimethylglycine (TMG) to support the pathways responsible for this process.* When functioning efficiently, these pathways help support heart health, brain function, and immune health.* Factors such as diet, lifestyle habits, and individual health needs can influence homocysteine metabolism, so results may vary from person to person.*

Homocysteine Supreme™ offers three key benefits: support for normal methylation, heart health, and cognitive function.* These benefits are powered by bioactive forms of vitamins B2, B6, folate (as Quatrefolic® 5-MTHF), vitamin B12 (as MecobalActive® methylcobalamin), and Trimethylglycine (TMG).* Methylation can be thought of as a set of tiny “on/off switches” that helps regulate important processes within every cell. When functioning properly, these processes support heart health, brain function, normal detoxification, and a balanced immune response.* To work efficiently, methylation depends on key nutrients, including B vitamins and methyl donors such as TMG.* Homocysteine Supreme™ provides these nutrients in bioactive forms that are readily absorbed and utilized by the body.* Together, they help support healthy methylation and homocysteine metabolism.*

The recommended amount of Homocysteine Supreme™ is 2 capsules per day, taken with meals. Always follow the guidance of your healthcare practitioner, as they may adjust the serving based on your individual health needs.

If you have any questions about this product or whether it is right for you, consult your healthcare practitioner for personalized advice.*

Homocysteine Supreme™ contains a blend of bioactive B vitamins and Trimethylglycine (TMG) to support healthy homocysteine metabolism, a natural process involved in protein metabolism.* Factors such as poor diet, inadequate B-vitamin intake, smoking, and physical inactivity can place additional demands on these pathways and affect their efficiency, which may impact heart, brain, and immune health.*

The formula includes vitamin B2 and vitamin B6 to support enzymes involved in homocysteine metabolism,* along with folate as Quatrefolic® (5-MTHF), vitamin B12 as MecobalActive® (methylcobalamin), and Trimethylglycine (TMG) to provide methylation support and help maintain healthy homocysteine metabolism.* Together, these nutrients support healthy methylation as well as cardiovascular, cognitive, and immune health.*

When taken as directed, Homocysteine Supreme™ may support heart health, brain function, immune health, and healthy detoxification by supporting healthy homocysteine metabolism.* Several factors can influence how efficiently these pathways function, including diet, B-vitamin status, genetic variations that affect B-vitamin metabolism and methylation, and lifestyle factors such as smoking and physical inactivity.* Your healthcare practitioner can help determine the most appropriate approach based on your individual health needs and circumstances.*

Homocysteine Supreme™ is designed for use when taken as directed. The recommended amount is 2 capsules per day, taken with meals. Your healthcare practitioner may adjust this based on your individual health needs.*

The bioactive forms of B vitamins in this formula are designed for enhanced absorption, allowing your body to use them more easily and efficiently.*

As with any supplement, consult your healthcare practitioner about your specific circumstances and any questions before starting this product.*

Both Homocysteine Supreme™ and B-Supreme by Designs for Health contain B vitamins and TMG, but they serve different purposes.*

Homocysteine Supreme™ is formulated specifically to support homocysteine metabolism.* It provides the four key nutrients involved in this pathway — vitamin B2, vitamin B6, folate as Quatrefolic®, and vitamin B12 as MecobalActive® — in bioactive forms, along with TMG as a methyl donor.* This targeted formula is part of Designs for Health’s cardiovascular health category and may be especially beneficial for those seeking focused nutritional support for homocysteine metabolism.*

B-Supreme is a full-spectrum B complex containing all eight B vitamins, plus choline and TMG.* Although it also supports healthy homocysteine metabolism, its primary focus is broader nutritional support for energy production, mitochondrial function, methylation, and cellular health.* It is part of Designs for Health’s foundational health category for individuals seeking comprehensive daily B vitamin support.*

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.