SKU: HTN

HTN Supreme™

Promotes Healthy Blood Pressure*

A targeted formula of bonito peptides and grape seed extract (Vitis vinifera) to help promote normal blood pressure and antioxidant status.*

Provides standardized and beneficial amounts of bonito peptide powder (1.5 g) and grape seed extract (200 mg) per serving.


• Supports healthy blood pressure*
• Promotes healthy blood vessels*
• Supports proper platelet function*
• Helps facilitate healthy blood flow*
• Supports cardiovascular health*
• Supports a balanced antioxidant status*

Recommended Use: Take 4 capsules per day or as directed by your health-care practitioner. (Divided dosing recommended.)

Bonito peptides and grape seed extract for healthy blood pressure*

Bonito peptides support cardiovascular health by promoting healthy blood vessel relaxation and fluid balance to help maintain normal blood flow.* Grape seed extract supports antioxidant status and the activity of endothelial nitric oxide synthase, an enzyme involved in nitric oxide production that helps relax and dilate blood vessels to support healthy circulation.*

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.