SKU: NTS

Natto-Serrazime™

Promotes Healthy Circulation*

A blend of two proteolytic enzymes to support the body's ability to properly break down cellular debris and damaged proteins.* May help promote healthy circulation.*

A blend of two health-promoting proteolytic enzymes, Nattozimes® and Serrazimes®, derived from the fungi Aspergillus oryzae and Aspergillus melleus.*

• Supports a healthy circulatory system*
• Promotes cardiovascular health*
• May help support joint health, immune function, and normal inflammatory responses*

Recommended Use:Take 1 capsule per day or as directed by your health-care practitioner.

Proteolytic enzyme blend

This formula is designed to support the body’s ability to break down and remove damaged cellular debris, tissue, and specific protein structures that are produced during the natural inflammatory process in response to trauma or injury.* These proteolytic enzymes may help maintain healthy joints, support healthy circulatory, respiratory, and immune function, and promote a normal inflammatory response.*

Natto-Serrazime™ by Designs for Health delivers two potent proteolytic enzymes, Nattozimes® and Serrazimes®, derived from the natural fungal sources Aspergillus oryzae and Aspergillus melleus.* Together, these enzymes support the breakdown and removal of damaged proteins and tissue that accumulate during the body’s natural response to physical trauma and stress.* Through these natural cleanup processes, Natto-Serrazime™ is formulated to support cardiovascular health, healthy circulation, and healthy inflammatory responses.*

Natto-Serrazime™ is specifically formulated to support cardiovascular health and healthy circulation.* The proteolytic enzymes Nattozimes® and Serrazimes® help support healthy blood flow by assisting the body’s natural breakdown and clearance of fibrous protein debris that can accumulate in and around blood vessels over time.*

What are the key benefits of Natto-Serrazime™?Natto-Serrazime™ by Designs for Health offers broad support for cardiovascular health, healthy circulation, and healthy inflammatory responses through its two proteolytic, or protein-clearing, enzymes: Nattozimes® and Serrazimes®.* These enzymes act as the body’s natural cleanup crew, helping break down and remove old proteins and cellular debris throughout the body.*

For cardiovascular health, the enzymes help support healthy blood flow by assisting in the breakdown of fibrous protein debris that can accumulate in and around blood vessels.* The formula also supports a healthy inflammatory response by assisting in the normal removal of proteins produced during the body’s natural healing process once recovery is underway.*

Taking Natto-Serrazime™ is simple and straightforward.* The recommended use is one capsule per day on an empty stomach, or as directed by your healthcare practitioner.* Taking it on an empty stomach allows the proteolytic enzymes to be absorbed and work throughout the body, where they can support the body.*

Natto-Serrazime™ contains two active proteolytic, or protein-clearing, enzymes.* The first is Nattozimes® (129 mg, 4,516 FU), an exo/endo protease derived from the fungus Aspergillus oryzae.* The second is Serrazimes® (33 mg, 20,000 U), an exo/endo protease derived from the fungus Aspergillus melleus.* Together, these enzymes act as the body’s natural cleanup crew by breaking down proteins into smaller building blocks called amino acids so the body can recycle or remove them.*

With consistent use, Natto-Serrazime™ may help support healthy cardiovascular function, healthy circulation, healthy inflammatory response, and overall well-being.* These benefits are supported by its two proteolytic enzymes, Nattozimes® and Serrazimes®, which help the body break down and clear away old proteins and cellular debris that can accumulate over time in blood vessels and other tissues.*

Because this formula works by supporting the body’s natural protein-clearing processes, individual results may vary depending on each person’s health status and lifestyle factors.* For best results, Natto-Serrazime™ should be taken as directed, one capsule per day on an empty stomach.* Your healthcare practitioner can help tailor use to your individual needs and wellness goals.*

Natto-Serrazime™ is designed for daily use when taken as directed. The recommended use, as stated by Designs for Health, is one capsule per day on an empty stomach, or as directed by your healthcare practitioner.

As with any supplement, every person's health needs are different. Designs for Health recommends consulting with your healthcare practitioner about your specific circumstances and any questions you may have before taking this product. A qualified practitioner can help you determine whether Natto-Serrazime™ is the right fit for your individual health goals.*

Both Natto-Serrazime™ and standard digestive enzymes like Digestzymes™ contain enzymes that break down proteins, but they are designed for very different purposes and work in different ways.*

Natto-Serrazime™ is formulated for whole-body, or systemic, support.* Its two fungal-derived proteolytic enzymes, Nattozimes® and Serrazimes®, are designed to work beyond digestion.* When taken on an empty stomach, they are absorbed into the bloodstream and help clear old protein buildup and cellular debris that can accumulate in blood vessels and tissues throughout the body.* This is why Natto-Serrazime™ may support cardiovascular health, healthy circulation, and healthy inflammatory responses.*

Digestzymes™, by contrast, is formulated specifically for digestive support in the GI tract during meals.* It contains a broad blend of enzymes, including proteases, amylases, and lipase, along with betaine HCl to help break down proteins, fats, and carbohydrates from food.* It is intended to support healthy digestion and nutrient absorption and may be especially helpful for occasional gas, bloating, or fullness after eating.*

In short, Natto-Serrazime™ is designed to support the body’s natural protein-clearing processes throughout multiple body systems, while digestive enzyme formulas are designed primarily to help break down food in the gut.* Your healthcare practitioner can help determine which product, or combination of products, best fits your individual health needs.*

Designs for Health

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.