SKU: PROS

Probiotic Supreme DF™

15 Billion CFUs of Beneficial Probiotics*

Provides a proprietary blend of eight probiotic strains to help support GI microbial balance, gut motility, gut function, and immune health.* Delivered in a sustained-release formula.

Features eight clinically relevant, research-backed probiotic strains in every 1-caplet serving.

• Promotes healthy digestion and GI function*
• May promote mood health*
• Supports the gut-brain connection*
• Supports a healthy immune response*
• Promotes normal bowel function and motility*
• Promotes healthy gut microbial balance*

Recommended Use: Take 1 caplet per day with a meal or as directed by your health-care practitioner.

Effective formula with fully transparent probiotic strain identification

Probiotic Supreme DF™ is formulated for stability and potency, delivering targeted, research-backed probiotic support for gastrointestinal and immune health.* Its patented delivery technology helps protect delicate probiotic organisms from harsh stomach conditions, ensuring maximum viability and optimal delivery of live organisms to the lower intestinal tract, where they are most effective.*

Probiotic Supreme DF™ is a dairy-free probiotic supplement from Designs for Health that makes gut health simple.* In just one caplet per day, you get 15 billion live probiotic organisms — a clinically relevant amount — from eight well-researched strains of friendly bacteria.* It's also free of gluten, soy, and GMOs, making it a great choice for people with common food sensitivities.* Probiotic Supreme DF™ supports a balanced gut microbiome, healthy digestion, healthy immune response, and overall gastrointestinal function.*

Probiotic Supreme DF™ by Designs for Health is specifically designed to help support a healthy gut.* Each caplet delivers 15 billion live, friendly bacteria from eight well-researched strains — all chosen to work together to promote a balanced, well-functioning digestive system.* Individual results may vary based on diet, lifestyle, and baseline gut health.*

Key benefits include support for a healthy gut microbial balance, healthy gut motility and function, a normal immune response, optimal GI health, and may support a healthy repopulation of intestinal flora after antibiotic use.* Probiotic Supreme DF™ features probiosphere technology — a patented delivery system that protects the probiotic organisms from stomach acid and releases them over an extended time frame.* This means the eight strains in each caplet are more likely to reach the right place in your GI tract and do their job effectively.*

Take 1 caplet per day with a meal, or as directed by your health-care practitioner. Refrigeration recommended.

Probiotic Supreme DF™ by Designs for Health provides a dairy-free, proprietary blend of eight highly researched probiotic strains including B. lactis, L. acidophilus, L. casei, L. rhamnosus, L. salivarius, B. breve, B. longum, and S. thermophilus in one convenient caplet.* Each serving delivers 15 billion CFUs (colony-forming units), which is a measure of how many live probiotic organisms are in each dose.* The eight strains come from three well-studied probiotic families that work as a synergistic combination to promote GI health and gut microbial balance.*

Probiotic Supreme DF™ by Designs for Health is designed to help support key areas of gut and overall health, including a healthy gut microbial balance, healthy gut motility and function, a normal immune response, optimal GI health, and may support a healthy repopulation of intestinal flora after antibiotic use.* Results are influenced by consistency of use, proper storage, antibiotic use, and your individual health profile.*

Probiotic Supreme DF™ by Designs for Health is formulated for daily use, when taken as directed.* The recommended serving is 1 caplet per day, taken with a meal, or as directed by your health-care practitioner.* It is dairy-free, gluten-free, soy-free, and non-GMO, making it suitable for those with dairy sensitivities.* Because individual needs vary based on body weight, health history, and any other supplements or medications you may be taking, your health-care practitioner is best positioned to confirm the right approach for you.*

Both Probiotic Supreme DF™ and the ProbioMed™ probiotic line are Designs for Health formulas designed to support gut microbiome health, GI function, and immune health.* They share foundational properties, but differ in potency, delivery format, refrigeration requirements, and who each product is best suited for.*

Probiotic Supreme DF™ (15 billion CFU across eight strains) uses patented probiosphere technology in a caplet form designed to protect probiotics from stomach acid and release them over an extended time frame.* Refrigeration is recommended for maximum potency and shelf life.* Probiotic Supreme DF™ may be optimal for those requiring higher amounts of probiotic species to support intestinal health and function.* ProbioMed™ products (50 and 100 billion CFU) are shelf-stable capsules with ten strains for daily gut support (50 billion CFU) or higher-potency replenishment (100 billion CFU).* Both products are dairy free.* Always consult your health-care practitioner to determine which probiotic formula is the right fit for your individual health needs and goals.*

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.