SKU: SAM

SAMe

Methylation support*

Supportive blend of S-adenosyl-L-methionine (SAMe) and bioavailable B vitamins to help support brain and liver health.* May encourage a positive mental outlook, memory, and balanced mood.*

200 mg of stabilized SAMe per serving, plus methylated forms of folate and vitamin B12 for enhance bioavailability and methylation support.*

• Promotes healthy methylation status*
• Supports normal cellular metabolism*
• Helps support brain and liver health*
• May promote a positive mental outlook, memory, and balanced mood*
• Helps supports glutathione and antioxidant status*
• Helps supports healthy homocysteine metabolism*

Recommended Use: Take 1 capsule per day, preferably on an empty stomach, or as directed by your health-care practitioner.

S-adenosyl-L-methionine (SAMe) is the body's primary methyl donor

SAMe is integral to overall health as it serves as the body’s principal methyl donor — a methyl group is a necessary molecule added to another compound to support its proper function.* This process is called methylation, a continuous cycle involved in the synthesis and healthy functioning of neurotransmitters, proteins, hormones, DNA and RNA, and glutathione (the body’s master antioxidant).* Supporting SAMe status supports many physiological processes, including brain and liver function.*

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.