SKU: SPM

SPM Supreme™

Immune and Inflammatory Response Support*

A synergistic combination of three specialized pro‑resolving mediators (SPMs) and omega-3 fatty acids to help support a normal inflammatory response and the body's normal healing process.*

Supports the body’s normal repair process, helping to promote a quick return to everyday activities.* May be supportive after times of physical injury.*

• Supports a normal inflammatory response*
• May provide support for occasional muscle and joint discomfort*
• Promotes the body’s normal tissue repair processes*
• Promotes a normal pain response*

Recommended Use: Take 2 softgels per day or as directed by your health-care practitioner.

Specialized pro-resolving mediators (SPMs)

SPMs are compounds naturally produced by the body, which help to support the body’s ability to respond to physical challenges and help resolve the initial steps in the inflammatory process.* SPM Supreme™ is uniquely formulated to help promote a normal pain response.*

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Designs for Health

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.