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SKU: TBS

Tri-Butyrin Supreme™

Highly Potent Butyrate | Post-biotic

Delivers a unique fusion of three butyrate molecules. Butyrate is a short-chain fatty acid that supports gut barrier integrity, immune function, and regular bowel movements.*

Features 300 mg of tributyrin (as CoreBiome™), which has the ability to deliver butyrate to the colon compared to sodium butyrate.*

• Supports a strong gut lining and a healthy balance of gut bacteria*
• Provides quick energy to fuel the gut-brain axis*
• Supports gut-associated immune function*
• May help occasional constipation by promoting regular bowel movements*

Recommended Use: Take 1 softgel per day or as directed by your health-care practitioner.

Support gut health with postbiotics*

Gut health doesn’t stop with pre- and probiotics. Tri-Butyrin Supreme™ represents a new approach to gut health and immune function — powered by postbiotics.* "Postbiotics” are health-promoting compounds produced by friendly gut microbes when they break down and ferment dietary fiber. This product is also enhanced with black cumin seed oil and medium-chain triglycerides for superior absorption.

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

©2019-2026 Designs for Health, Inc. All rights reserved.

The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.