SKU: TRI

Trifolamin™

Methylation Support*

Bioavailable combination of three forms of B12 with active folate for healthy cellular, neurological, and methylation support in a tasty orange-flavored lozenge.*

A synergistic combination of three bioavailable forms of vitamin B12, including methylcobalamin, hydroxycobalamin, and adenosylcobalamin, with a patented active form of folate as 5-MTHF.

• Supports healthy vitamin B12 and folate status*
• Promotes neurological health*
• Supports healthy cellular energy metabolism*
• Promotes cellular repair and function*
• Promotes healthy cognition and mood*
• Supports healthy fetal development*

Recommended Use: Take 1 lozenge per day or as directed by your health-care practitioner. Allow lozenge to dissolve slowly and completely in mouth and swallow.

Easy absorption of B12 and folate

The lozenge delivery system of Trifolamin™ allows for absorption of vitamin B12 and folate to begin upon ingestion, bound by a protein secreted in the saliva that carries vitamin B12 to the gastrointestinal tract. Folate is included due to its synergistic properties with vitamin B12.*

Designs for Health

Terms & Conditions

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.