Clinical and Case Studies

The publications referenced on this page are for educational and informational purposes only. They reflect the findings and conclusions of the original authors under specific study conditions and are not intended to represent typical results or guarantee similar outcomes. Individual responses may vary. The information on this page is not intended as medical advice and should not replace consultation with a qualified healthcare professional. Certain authors of these publications were employed by or received compensation from Designs for Health in connection with the applicable study.

Biomedical Journal of Scientific & Technical Research • Vol. 66, Issue 2 • July 29, 2026 • pp. 58595–58601

Allulose-Containing Gummy (GlucoSupreme™) Reduces Postprandial Glucose and Glycemic Variability in Healthy Adults Monitored by Continuous Glucose Monitoring: A Case Series

Seamus Kelly; Oscar Coetzee, MS, DCN; Danielle Arnold; Sahana Prakash

This case series examines an allulose-containing gummy taken with meals and its association with lower post-meal glucose and reduced within-day glycemic variability in healthy adults monitored by continuous glucose monitoring.

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Biomedical Journal of Scientific & Technical Research • Vol. 66, Issue 1 • July 8, 2026 • pp. 58337–58351

Multimodal Integrative Therapy in a Former NFL Player with Post-Concussive Syndrome and Early-Onset Cognitive Decline: A Case Report

Justin Dearing, DC, DACNB, FIAMA, FAARM; Melanie Luther; Seamus Kelly; Oscar Coetzee, MS, DCN

This case report describes an 18-month multimodal integrative program combining targeted nutraceutical support, oxygen and regenerative therapies, and rehabilitation, with improvements measured across cognitive, hematologic and body-composition domains.

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Biomedical Journal of Scientific & Technical Research • Vol. 66, Issue 1 • July 8, 2026 • pp. 58337–58351

Diamine Oxidase Supplementation for Histamine Regulation in Constipation-Predominant Irritable Bowel Syndrome: A Case Report

Integrative Medicine • Vol. 25, No. 2 • April 2026

Increasing Leukocyte and Neutrophil Count with Vitamin C Supplementation: A Case Report

Pamela K. B. Cho, MS; Mary Gordon, MS; Oscar Coetzee, MS, DCN

This case report examines the use of vitamin C supplementation to support healthy leukocyte and neutrophil counts, highlighting its role in immune cell function and overall immune resilience.

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Biomedical Journal of Scientific & Technical Research • Vol. 65, Issue 1 • March 20, 2026 • pp. 57278–57286

Gastrointestinal Functional Testing-Informed Protocol Associated with Improvement in Gastrointestinal and Joint Symptoms: A Case Report

Constance Karstens, MS; Chaana Rosenthal; Sara Wilson; Oscar Coetzee

This case report examines a gastrointestinal testing-informed nutraceutical protocol associated with improvements in digestive complaints and joint symptoms, highlighting the connection between gut health and musculoskeletal comfort.

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Archives of Healthcare • Vol. 6, Issue 1 • 2026 • pp. 7–23

Integrative Management of Estrogen Dominance, Methylation Impairment, and Histamine Intolerance in Perimenopause: A Case Report

Sarah Doyle, DPT, CFMP, DACBN; Jaclyn Rosen; Kevin Knight; Oscar Coetzee

This case report examines an integrative approach to estrogen dominance, methylation impairment, and histamine intolerance in perimenopause, highlighting targeted nutraceutical support for hormonal balance and histamine regulation.

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Annals of Case Reports • Volume 11; Issue 01 • January 2026

Anaerostipes caccae CLB101™, a Novel Probiotic and Key Butyrate Producer, Aids in the Resolution of Long-Term Food Intolerances in a Patient in 12 Weeks: A Case Report

Oscar Coetzee, MS, DCN; Danielle Arnold, MS, CNS, LN

This case report details a targeted probiotic intervention in a 47-year-old female with long-term food intolerances, digestive discomfort, and disrupted gut microbial balance, highlighting improvements in food tolerance and key butyrate-producing anaerobic taxa after 12 weeks of Anaerostipes caccae CLB101™ supplementation.

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Alternative Therapies in Health and Medicine • Jan/Feb 2026 • Vol. 32, No. 1 • pp. 56–59

DIM and PSA Reduction: Blocking Aromatization for Prostate Health: A Case Report

Danielle Arnold, MS, CNS, LDN; Oscar Coetzee, MS, DCN; Allyson LaGrutta, MS

This case study examines the use of diindolylmethane (DIM) to support healthy estrogen metabolism, reduce PSA levels, and improve hormonal balance in a 78-year-old male patient.

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Women’s Health Research • Vol. 5, Issue 1 • 2025 • pp. 24–38

Urinary Metabolite Testing, Nutraceutical Intervention and (7 x Method Program) in the Management of Menopause Symptoms: A Case Report

Sarah Doyle, DPT, CFMP, DACBN; Pamela K.B. Cho, MS; Danielle Arnold, MS; Oscar Coetzee, MS, DCN

This case report examines a comprehensive dietary and nutraceutical program, guided by at-home urinary hormone metabolite testing, associated with improvements in mood, metabolic markers, and hormone metabolites in a 61-year-old postmenopausal woman.

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Journal of Food & Nutritional Sciences • Vol. 6, Issue 1 • 2025 • pp. 88–94

Fecal Calprotectin Improvement in Crohn’s Disease Pediatric Patient with Targeted Nutraceutical Approach: A Case Report

Frank Bodnar; Jesse Martin; Oscar Coetzee

This case report details a functional nutrition approach for an 11-year-old male with Crohn’s disease and elevated fecal calprotectin, highlighting improvements following targeted nutraceutical support.

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Annals of Case Reports • Vol. 10, Issue 06 • December 9, 2025 • 10: 2467

Case Report: Homocysteine Reduction in 7 Patients Using a Hcy-Supporting Nutraceutical

Michael Jurgelewicz; Oscar Coetzee

This case report reviews seven patients with elevated homocysteine levels, highlighting the use of a targeted nutraceutical approach to support healthy methylation, cardiovascular function, and overall metabolic health.

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Alternative Therapies in Health and Medicine • Nov/Dec 2025 • Vol. 31, No. 6 • pp. 54–59

Hyperlipidemia, Hypercholesterolemia, Hypertriglyceridemia, and Glycemic Response Improvement in a 60-year-Old Male with Metabolic Syndrome Through a Personalized Six-Month Nutraceutical/Diet Protocol: A Case Report

David M. Brady, ND; Oscar Coetzee, MS, DCN

This case report examines a targeted nutraceutical and dietary protocol associated with improvements in lipid markers and glycemic response in a patient with hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

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Alternative Therapies in Health and Medicine • Sep/Oct 2025 • Vol. 31, No. 5 • pp. 52–57

Boosting Testosterone Naturally in Hashimoto’s: A Case Report on Trans-Geranylgeraniol Supplementation

Allyson LaGrutta, MS, CNS; Danielle Arnold, MS, CNS, LN; Oscar Coetzee, MS, DCN

This case report details an integrative nutrition approach for a 27-year-old male with Hashimoto’s thyroiditis, suboptimal testosterone levels, and gut dysbiosis, highlighting the role of trans-geranylgeraniol supplementation in supporting healthy hormone balance and metabolic function.

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Journal of Human Nutrition • Vol. 1, Issue 1 • October 16, 2017 • pp. 14–18

Prosthetic Hip-Associated Cobalt Toxicity (PHACT) Reversal through Nutrition Supplementation and Dietary Intervention

Oscar Coetzee; Angela Mari

This case report examines a targeted nutraceutical and whole-foods dietary intervention associated with reductions in cobalt and chromium levels in a 62-year-old male with prosthetic hip-associated cobalt toxicity, highlighting nutritional support for the body’s natural detoxification pathways.

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