Skip To Main Content
Annatto-E® Synergy
Delta- and Gamma-Tocotrienols and Black Cumin Seed Oil
Vitamin E tocotrienols plus black cumin seed oil acts as a synergistic blend to promote healthy inflammatory responses, lipid metabolism, and antioxidant status.*
A unique tocopherol-free, tocotrienols-only product containing 125 mg tocotrienols along with 1 g black cumin seed oil (Nigella sativa) per 2-softgel serving.
•Promotes cardiovascular health*
• Supports metabolic health*
• Supports liver health*
• Supports antioxidant status*
• Supports healthy inflammatory responses*
• May help support respiratory and bone health*
Recommended Use: Take 2 softgels per day or as directed by your health-care practitioner.
Vitamin E and black cumin seed oil promotes heart health and antioxidant status*
Our formula combines black cumin seed oil with the two most bioactive forms of vitamin E tocotrienols (gamma and delta). These forms of vitamin E are shown to provide superior support for heart, liver, and cellular health compared to other vitamin E compounds.* Most conventional supplements are typically rich in tocopherols (alpha‑tocopherol, in particular). However, the tocotrienol forms of vitamin E have beneficial effects across various body systems that allow them to uniquely support overall wellness.*
Helpful Product Resources
Compare Annatto-E® Synergy with all Designs for Health products, review research and education resources, or visit the product and ordering FAQs for additional support.
Annatto-E® Synergy is a combination formula by Designs for Health that pairs DeltaGold® tocotrienols (the preferred form of vitamin E) with black cumin seed.* This synergistic blend supports cardiovascular health, metabolic function, antioxidant status, immune balance, brain health, and respiratory wellness.*
Annatto-E® Synergy is formulated to support immune balance, metabolic health, and antioxidant status through its combination of tocotrienols, which are forms of vitamin E, and thymoquinone from black cumin seed.* The synergistic pairing promotes full-body support.* Individual results may vary based on diet, lifestyle, and overall health status.*
Key benefits include support for cardiovascular health, metabolic function, antioxidant status, balanced immune responses, brain health, and respiratory wellness.* These benefits are supported by the synergistic combination of annatto-derived tocotrienols and the active compound thymoquinone from black cumin seed.*
Take two softgels per day, or as directed by your healthcare practitioner. For best results, use consistently as part of your daily wellness routine.* Consider spacing intake at least 6 hours from supplements containing alpha-tocopherols to optimize tocotrienol benefits.*
Annatto-E® Synergy contains DeltaGold® delta- and gamma-tocotrienols, which are forms of vitamin E, from annatto seeds for antioxidant status and metabolic support.* It also includes black cumin seed, whose active compound thymoquinone promotes immune system balance and supports respiratory and bone health.*
You may notice support for metabolic wellness, immune resilience, and overall vitality with regular use.* The synergistic pairing of tocotrienols and black cumin seed promotes multiple body systems.* Results depend on baseline health, diet, lifestyle habits, and healthcare practitioner guidance.*
Annatto-E® Synergy is designed for daily use when taken as directed.* It features naturally derived ingredients from annatto seeds and black cumin seed.* Consult your healthcare practitioner before use if you are pregnant, nursing, taking medications, or managing a health condition.*
Annatto-E® Synergy builds upon standard Annatto-E® by adding black cumin seed with its active compound thymoquinone.* This combination expands the formula's scope to include additional immune, respiratory, and bone health support beyond what tocotrienols alone provide — offering a more comprehensive full-body formula.*
Annatto-E® Synergy
Tocotrienol and Black Cumin Seed Support for Cardiovascular Health, Metabolic Function, and Full-Body Wellness*
Key Performance Benefits
- Promotes cardiovascular health and normal cholesterol and triglyceride metabolism*
- Supports antioxidant status and healthy inflammatory responses*
- Supports metabolic health and normal body weight*
- Supports liver health*
- May help support respiratory and bone health*
- Promotes brain health and immune function*
What This Product Is
Annatto-E® Synergy features the preferred form of vitamin E (100% tocotrienols) combined with black cumin seed oil for comprehensive full-body support. Each two-softgel serving delivers 125 mg of DeltaGold® delta- and gamma-tocotrienols sourced from annatto along with 1 g of black cumin seed oil (Nigella sativa), creating a synergistic formula that promotes cardiovascular, metabolic, and immune health.*
Compared to alpha-tocopherols (another form of vitamin E), the delta- and gamma-tocotrienols in this product may promote metabolic health by supporting normal body weight and a healthy inflammatory response, which can be especially important for those concerned with liver health. The combination of tocotrienols and black cumin seed offers broader support than either ingredient alone, extending benefits to respiratory and bone health.*
Mechanism of Action
Cardiovascular and Metabolic Support
DeltaGold® tocotrienols promote normal cholesterol and triglyceride metabolism, supporting cardiovascular health. The delta- and gamma-tocotrienol forms may promote metabolic health by supporting normal body weight and healthy inflammatory responses, which is particularly relevant for liver health and overall metabolic function.*
Immune and Inflammatory Response
The active compound in black cumin seed, thymoquinone, promotes a healthy inflammatory response and supports immune system balance. Combined with the antioxidant properties of tocotrienols, this dual-action formula provides comprehensive support for the body’s inflammatory and immune pathways.*
Respiratory, Bone, and Brain Health
Black cumin seed provides support for normal respiratory health and lung function, while the combination of tocotrienols and black cumin seed may also support bone health. Annatto-E® Synergy additionally promotes brain health through the neuroprotective and antioxidant properties of both tocotrienols and black cumin seed compounds.*
Applications
- Individuals seeking comprehensive cardiovascular and metabolic health support*
- Those looking to support antioxidant status and healthy inflammatory responses*
- Individuals seeking to promote liver health and normal body weight*
- Those looking to support immune function and respiratory health*
- Individuals seeking synergistic tocotrienol and black cumin seed benefits for full-body wellness*
Key Ingredients / Formula Highlights
DeltaGold® Tocotrienols (125 mg per serving)
Delta- and gamma-tocotrienols derived from annatto seeds that promote metabolic, liver, cardiovascular, respiratory, and bone health. Vitamin E tocotrienols also support antioxidant status and healthy inflammatory responses.*
Black Cumin Seed Oil (1 g per serving)
Derived from Nigella sativa, a commonly used spice with a long history of supporting various health conditions. The active compound thymoquinone promotes a healthy inflammatory response, supports immune system balance, and provides support for normal respiratory health and lung function.*
Clean Formula Design
Gluten-free, dairy-free, soy-free, and non-GMO. Synergistic two-ingredient formula for comprehensive support.
Suggested Use
Take 2 softgels per day or as directed by your health-care practitioner.
Product Questions
Why are tocotrienols and black cumin seed combined in this formula?
Tocotrienols and black cumin seed offer complementary mechanisms of action that provide broader full-body support than either ingredient alone. Together they promote cardiovascular, metabolic, immune, respiratory, and bone health while supporting antioxidant status and healthy inflammatory responses.*
How does Annatto-E® Synergy differ from Annatto-E®?
Annatto-E® provides tocotrienols alone for focused vitamin E tocotrienol support, while Annatto-E® Synergy adds 1 g of black cumin seed oil for expanded benefits including immune system balance, respiratory health support, and enhanced inflammatory response modulation through the active compound thymoquinone.*
Who may benefit most from Annatto-E® Synergy?
Individuals seeking comprehensive full-body support may benefit, particularly those looking to promote cardiovascular and metabolic health, support liver function, maintain healthy inflammatory responses, and support immune and respiratory health through a synergistic tocotrienol and black cumin seed formula.*
Practitioner Reference
Annatto-E® Synergy is positioned within the Designs for Health Foundational Health category. Available as ANTS60 (60 softgels). This product is intended for use under the guidance of a licensed health-care practitioner.