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B-Supreme
Bioactive B Vitamin Complex
A potent B vitamin complex formulated with bioidentical and coenzymated forms of B vitamins for enhanced nutrient absorption and bioavailability.
Features folate, as Quatrefolic® 5-methyltetrahydrofolate (5-MTHF), and vitamin B12, as methylcobalamin — the body’s preferred forms of these vitamins.
• Supports B vitamin status in the body*
• Promotes the optimal intake of essential micronutrients for overall health*
• Supports cardiovascular and metabolic health*
• May be helpful for individuals following a vegan or vegetarian diets, or those with insufficient dietary B vitamin intake*
Recommended Use: Take 1 capsule per day with a meal or as directed by your health-care practitioner.
Choline and trimethylglycine (TMG) for extra support*
Choline is a vitamin-like, essential nutrient that is similar in structure to other B vitamins and must be consumed in the diet to maintain optimal health. It is an essential structural component of all cell membranes, which is involved in many bodily processes, including normal metabolism, methylation, and neurotransmitter production. TMG, also known as betaine, is also an important cofactor in methylation, which is a process that occurs in all cells, and is required for cardiovascular and cognitive health.*
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B-Supreme is a comprehensive B vitamin complex by Designs for Health that delivers all eight essential B vitamins in the body's preferred, pre-activated coenzymated forms.* It features methylated folate (as Quatrefolic®) and methylcobalamin (as MecobalActive®), plus choline and trimethylglycine (TMG) to support methylation and cellular health.*
B-Supreme is formulated to support healthy energy production and normal methylation through bioactive B vitamins, choline, and trimethylglycine (TMG).* B vitamins are essential for one-carbon metabolic reactions that support homocysteine metabolism.* Individual results may vary based on diet, genetic factors, and overall health status.*
Key benefits include support for B vitamin status, cardiovascular and metabolic health, energy production, and healthy methylation pathways.* These benefits are driven by coenzymated B vitamin forms, methylated folate and B12, plus choline and TMG for comprehensive methylation support.*
Take one capsule per day with a meal, or as directed by your healthcare practitioner. B vitamins are water-soluble and cannot be stored in the body, making consistent daily intake important. B-Supreme is delivered in a vegetable capsule suitable for vegetarians and vegans.
B-Supreme contains all eight essential B vitamins in coenzymated forms, including Quatrefolic® 5-MTHF folate and MecobalActive® methylcobalamin for superior bioavailability.* It also includes choline and trimethylglycine (TMG) to support methylation pathways, DNA function, and healthy homocysteine metabolism.*
You may notice support for energy production, mental clarity, and overall vitality with regular use.* B vitamins are water-soluble and must be replenished daily for optimal function.* Results are influenced by dietary intake, genetic methylation factors such as MTHFR variations, which can affect how the body uses certain B vitamins, stress levels, and practitioner guidance.*
B-Supreme is designed for daily use when taken as directed.* Its coenzymated and methylated forms are well-tolerated and readily utilized by the body.* Consult your healthcare practitioner before use if you are pregnant, nursing, taking medications, or managing a health condition.*
B-Supreme stands apart by using coenzymated, bioidentical forms of all eight B vitamins — including methylated folate and B12 — rather than synthetic forms found in many standard formulas.* The addition of choline and TMG provides targeted methylation support not typically found in conventional B complex supplements.*
B-Supreme
Coenzymated B Vitamin Complex with Methylated Folate, B12, Choline, and TMG for Methylation and Cellular Health*
Key Performance Benefits
- Supports B vitamin status in the body*
- Promotes the optimal intake of essential micronutrients for overall health*
- Supports cardiovascular and metabolic health*
- May be helpful for individuals following vegan or vegetarian diets*
What This Product Is
B-Supreme is a comprehensive B vitamin complex formula designed to promote micronutrient status for optimal cellular function and overall health. It supplies targeted amounts of B vitamins in the body’s preferred pre-activated forms, where appropriate, to be used more readily and easily. B-Supreme contains the methylated forms of folate (as Quatrefolic® [6S]-5-methyltetrahydrofolate) and vitamin B12 (as MecobalActive® methylcobalamin) for superior bioavailability.*
Choline and trimethylglycine (TMG) are added to help support methylation pathways and optimal DNA function. B vitamins are a family of eight water-soluble micronutrients needed in small amounts by the body. Unlike fat-soluble vitamins, water-soluble vitamins cannot be stored, so adequate amounts must be consumed daily either through food or supplements. B vitamins are needed for one-carbon metabolic reactions that support proper methylation, healthy homocysteine metabolism, and normal energy production.*
Mechanism of Action
Methylation and Homocysteine Metabolism
B vitamins are essential for one-carbon metabolic reactions that support proper methylation and healthy homocysteine metabolism. The methylated forms of folate and B12 in this formula are the body’s preferred forms, supporting these critical pathways without requiring additional enzymatic conversion. TMG is an important cofactor in methylation, involved in the production of neurotransmitters and coenzyme Q10.*
Choline and Cellular Health
Choline is a vitamin-like, essential nutrient that is an essential structural component of all cell membranes. It is involved in many bodily processes including normal metabolism, methylation, and neurotransmitter production. The need for choline is increased during pregnancy and is essential for proper brain development.*
Energy Production and Cellular Function
B vitamins are involved in reactions related to normal energy production and cellular function. The bioidentical and coenzymated forms used in this formula enhance nutrient absorption and bioavailability, ensuring the body can readily utilize these essential micronutrients.*
Applications
- Individuals seeking comprehensive B vitamin support with bioavailable, pre-activated forms*
- Those looking to support healthy methylation pathways and homocysteine metabolism*
- Vegans and vegetarians who may be at risk for B vitamin deficiencies*
- Individuals seeking to support cardiovascular, metabolic, and neurological health*
- Those looking for a complete B complex with added choline and TMG for methylation support*
Key Ingredients / Formula Highlights
Methylated Folate and Vitamin B12
Features the naturally occurring forms of folate as Quatrefolic® [6S]-5-methyltetrahydrofolate (MTHF) and vitamin B12 as MecobalActive® methylcobalamin — the body’s preferred forms of these vitamins for optimal bioavailability and methylation support.*
Choline and Trimethylglycine (TMG)
Added to support healthy methylation pathways and optimal DNA function. Choline is an essential structural component of cell membranes involved in metabolism, methylation, and neurotransmitter production. TMG is an important methylation cofactor.*
Clean Formula Design
Gluten-free, dairy-free, soy-free, vegan, and non-GMO. Vegetable capsule suitable for vegetarians and vegans.
Suggested Use
Take 1 capsule per day with a meal or as directed by your health-care practitioner.
Product Questions
Why does B-Supreme use methylated forms of folate and B12?
The methylated forms — Quatrefolic® MTHF and MecobalActive® methylcobalamin — are the body’s preferred, naturally occurring forms of these vitamins. They offer superior bioavailability and can be used directly without requiring additional enzymatic conversion.*
Why are choline and TMG included in a B vitamin complex?
Choline and TMG are important cofactors in methylation, which is a process that occurs in all cells. Methylation is involved in the production of neurotransmitters and coenzyme Q10, and promotes normal homocysteine metabolism. Including them alongside B vitamins provides comprehensive methylation pathway support.*
Who may benefit most from B-Supreme?
Individuals seeking comprehensive B vitamin support with pre-activated, bioavailable forms may benefit. Populations at particular risk for B vitamin deficiencies include vegans and vegetarians, pregnant women, elderly populations, those following calorie-restrictive diets, and those with compromised digestive function.*
Practitioner Reference
B-Supreme is positioned within the Designs for Health Foundational Health category. Available as BSP060 (60 vegetarian capsules), BSP090 (90 vegetarian capsules), and BSP120 (120 vegetarian capsules). Quatrefolic® is a registered trademark of Gnosis by Lesaffre. MecobalActive® is a registered trademark of Daiichi Fine Chemical Co., Ltd. This product is intended for use under the guidance of a licensed health-care practitioner.