SKU: BRF

BRF 45™

Supports Bone Health and Strength*

BRF 45™ may provide nutritional support for individuals who are at risk of bone loss, bone fracture, arterial stiffness, and other relevant conditions in which high amounts of vitamin K1 and/or vitamin K2 may be beneficial.*

Designs for Health’s most advanced vitamin K2 formula that targets bone health with clinically studied ingredients.*

• Supports optimal bone health and strength*
• Helps promote bone remodeling factors (BRF)*
• Promotes optimal vitamin K status*
• May help maintain optimal calcium and collagen content in bones*
• May benefit those taking certain medications that may increase demand for vitamin K*
• Promotes arterial elasticity and integrity*

Recommended Use: Take 2 softgels per day with meals, or as directed by your health-care practitioner (divided dosing recommended; 1 softgel with breakfast and 1 softgel with lunch or dinner).

Warning: Consult your health-care practitioner before using this product if you are taking Coumadin, warfarin, or other anticoagulant medications.

The power of vitamin K2 and geranylgeraniol (GG) for bone health*

Vitamin K2 helps activate the bone-building protein that binds calcium and helps move it into our bones and teeth (where we want it).* It also helps promote the bone remodeling process.* GG is a building block of vitamin K2 and is added to promote vitamin K2 (as MK-4) production.*

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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The Designs for Health Spotlight™ functional wellness tests are not diagnostic and are not eligible for coverage under Medicare, Medicaid, or medical insurance. DFH Spotlight testing must be ordered or authorized by a qualified health-care provider registered with DFH. Please reach out directly to your practitioner to express your interest in any of the Spotlight tests. Spotlight test kits are not available for purchase or shipping in New York or the U.S. territories.

††U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

¹Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042.

²Keystone commensal strains based on the HACK index. 8x comparison based on five keystone strains (up to 24% combined abundance) vs. single-strain Akkermansia  products (~3%). Percentages reflect typical abundance in healthy adult microbiomes per published research. Individual colonization varies.