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SKU: LSC

Lithium Synergy

Bioavailable Lithium Orotate with Methylation Support*

Features lithium orotate and B12 to support healthy mood, neurotransmitter function, and brain health.*

Delivers 5 mg of bioavailable lithium orotate per serving, combined with methylated vitamin B12 and trimethylglycine (betaine).

• Supports balanced mood*
• Supports brain health*
• Support healthy neurotransmitter balance*
• Supports methylation pathways*

Recommended Use: Take 1 capsule per day or as directed by your health-care practitioner.

Warning: This product should not be used to replace any anti-depressant medication, including prescription forms of lithium, unless used under the direction of a qualified health-care practitioner. Lithium Synergy™ should not be used by individuals with significant renal or cardiovascular diseases, severe debilitation, dehydration, or sodium depletion, or by individuals who are taking diuretics or angiotensin-converting enzyme (ACE) inhibitors. Consult your doctor before use if you are taking anti-hypertensive drugs, anti-inflammatory drugs, analgesic drugs, or insulin. Lithium should not be used by pregnant women and breastfeeding mothers. Serum lithium levels should be monitored by a qualified health-care provider during use.

Lithium orotate to support mood health*

Lithium orotate may help support healthy neurotransmitter balance and mood regulation.* It may also support a healthy sleep–wake cycle, helping promote a positive outlook and a balanced response to everyday stress.* Lithium is complemented by vitamin B12 and trimethylglycine (TMG), which support methylation and SAMe production, processes important for neurotransmitter activity, cognitive function, and emotional well-being.*

Lithium Synergy

Lithium Orotate with Vitamin B12 and Trimethylglycine (TMG) for Mood Support, Neurotransmitter Balance, Healthy Sleep Cycle, Methylation, and Cognitive Function*

Key Performance Benefits*

  • Supports a positive mood and balanced emotional response
  • Promotes healthy neurotransmitter balance
  • May support a healthy sleep cycle
  • Supports healthy methylation pathways
  • Supports cognitive function and mental energy

What This Product Is

Lithium Synergy provides lithium as lithium orotate, bound to orotic acid for improved bioavailability, along with vitamin B12 and trimethylglycine (TMG) to support psychological wellbeing and healthy methylation pathways. Lithium is a trace element with beneficial properties for the body and mind, particularly with regard to supporting neurotransmitters and other factors that influence moods, behavior, and brain health.*

Lithium may help influence levels of norepinephrine, dopamine, serotonin, and other neurotransmitters, facilitating a better balance between excitatory and inhibitory impulses and evening out the emotional response to situations. It may also support a healthy sleep cycle, helping to promote a positive outlook and a balanced response to stress. Some of lithium’s nutritional benefits may come from its ability to support the synthesis and recycling of inositol, a compound that may be helpful for supporting a positive mood.*

Mechanism of Action

Lithium Orotate for Neurotransmitter Balance and Mood*

Lithium as lithium orotate may help influence levels of norepinephrine, dopamine, serotonin, and other neurotransmitters, facilitating a better balance between excitatory and inhibitory impulses. It also supports the synthesis and recycling of inositol, a compound important for maintaining a positive mood.*

Sleep Cycle and Circadian Support*

Circadian disruption and suboptimal sleep can sometimes occur in individuals facing occasional challenges with mood and everyday stressors. Lithium may support a healthy sleep cycle, thus helping to promote a positive outlook and a balanced response to stress.*

B12 and TMG for Methylation and Cognitive Support*

Vitamin B12 is required for the synthesis of SAMe, a methyl donor that facilitates methylation reactions critical for producing neurotransmitters and other compounds involved in maintaining healthy, balanced moods. TMG helps support healthy methylation pathways alongside B12. Sufficient B12 status is also paramount for cognitive function and maintaining good physical energy levels.*

Applications

  • Individuals seeking mood support through neurotransmitter balance*
  • Those looking for healthy sleep cycle support*
  • Individuals wanting methylation pathway support for emotional health*
  • Those seeking cognitive function and mental energy support*
  • Individuals wanting comprehensive mood mineral support with B12 and TMG*

Key Ingredients / Formula Highlights

Lithium (as Lithium Orotate)

Bound to orotic acid for improved bioavailability. Supports neurotransmitter balance, mood, sleep cycle, and inositol synthesis and recycling.*

Vitamin B12 and Trimethylglycine (TMG)

B12 for SAMe synthesis and methylation reactions. TMG for additional methylation pathway support. Together they support neurotransmitter production, cognitive function, and emotional health.*

Suggested Use

Take 1 capsule per day, or as directed by your health-care practitioner.

Product Questions

How does Lithium Synergy compare to 5-HTP Synergy for mood support?

Lithium Synergy supports mood through lithium orotate’s influence on multiple neurotransmitters (norepinephrine, dopamine, serotonin), inositol recycling, and methylation support with B12 and TMG. 5-HTP Synergy focuses specifically on serotonin production through 5-hydroxytryptophan. Lithium Synergy offers a broader approach to neurotransmitter balance and mood support.*

Why are B12 and TMG included with lithium?

Many individuals do not have robust methylation due to genetic factors, and effective methylation is critical for producing neurotransmitters and compounds involved in healthy, balanced moods. Vitamin B12 is required for SAMe synthesis, and TMG provides additional methylation support, creating a synergistic formula for emotional health.*

Who may benefit most from Lithium Synergy?

Individuals seeking mood and emotional balance support, those with occasional challenges with mood and everyday stressors, people wanting healthy sleep cycle support, and anyone looking for comprehensive mood mineral supplementation with methylation pathway support.*

Practitioner Reference

Lithium Synergy is positioned within the Designs for Health Stress/Mood category. Available as LSC120 (120 capsules). This product is intended for use under the guidance of a licensed health-care practitioner.