SAMe

Stabilized S-Adenosyl-L-Methionine (SAMe, 200 mg) with Methylated Folate (5-MTHF), Methylcobalamin (Vitamin B12), and Vitamin B6 in Acid-Resistant Encapsulation for Brain Function, Mood Support, Liver Health, Methylation, Antioxidant Status, Cell Membrane Integrity, and Healthy Inflammatory Response*

Key Performance Benefits

• Helps support brain function and memory*

• May encourage a positive mental outlook and balanced mood*

• Supports healthy liver function*

• Helps support antioxidant status*

• May help reduce oxidative stress*

• May help support a healthy inflammatory response*

• Helps maintain cell membrane integrity and fluidity*

What This Product Is

SAMe provides 200 mg of patented, stabilized S-adenosyl-L-methionine per capsule to support biochemical pathways crucial to healthy cellular metabolism. SAMe is an internally produced compound found in every cell of the human body that is involved in more than 100 biochemical reactions. It is naturally synthesized from ATP and the amino acid methionine in the presence of adequate folate and vitamin B12. SAMe is highly concentrated in the liver, adrenal glands, and pineal gland, and is uniformly distributed throughout the brain.*

SAMe serves as the body's principal methyl donor, supporting the process of methylation — a continuous cycle involved in the synthesis and healthy functioning of neurotransmitters, phospholipids, proteins, hormones, DNA and RNA, polyamines, and glutathione. These capsules also provide vitamins B6, B12 (as methylcobalamin), and folate (as 5-MTHF), which are nutrient cofactors required for proper SAMe function. Unique acid-resistant encapsulation technology allows intact absorption into the small intestine for superior bioavailability.*

Mechanism of Action

SAMe as Principal Methyl Donor

SAMe (200 mg) serves as the body's principal methyl donor, supporting methylation — a continuous cycle involved in the synthesis and healthy functioning of neurotransmitters, phospholipids, proteins, hormones, DNA and RNA, polyamines, and glutathione.* Proper functioning of these substances is critical for optimal nervous, cardiovascular, and immune system activity, hormone balance, detoxification, genetic expression, and energy production.

Methylated B Vitamin Cofactors

The formula includes 5-methyltetrahydrofolate (5-MTHF / folate) and methylcobalamin (vitamin B12) in clinically relevant doses as methylated forms for enhanced bioavailability and methylation support. Vitamin B6 is also included. These cofactors are required for the proper and efficient function of SAMe in the body's biochemical pathways.*

Acid-Resistant Encapsulation

Unique encapsulation technology is designed to withstand the acidic environment within the stomach, allowing for intact absorption into the small intestine. This innovative technology also enables the inclusion of the B vitamin cofactors alongside stabilized SAMe for superior absorption and bioavailability.*

Applications

• Individuals seeking brain function, memory, and mood support*

• Those wanting methylation support with the body's principal methyl donor*

• Individuals needing liver function and detoxification support*

• Those seeking antioxidant status and cell membrane integrity support*

• Individuals with increased SAMe demand due to aging, stress, or dietary factors*

Key Ingredients / Formula Highlights

Stabilized SAMe with Methylated Cofactors

200 mg patented, stabilized SAMe per capsule. 5-MTHF (methylated folate) and methylcobalamin (vitamin B12) for enhanced methylation support. Vitamin B6 as additional cofactor.

Advanced Encapsulation

Acid-resistant technology for intact intestinal absorption. Available as SAM030 (30 vegetarian capsules) and SAM090 (90 vegetarian capsules). Gluten-free, dairy-free, soy-free. Non-GMO.

Suggested Use

Take 1 capsule per day, preferably on an empty stomach, or as directed by your health-care practitioner.

Product Questions

Why are methylated B vitamins included with SAMe?

SAMe is naturally synthesized in the body from ATP and methionine in the presence of adequate folate and vitamin B12. Including 5-MTHF (methylated folate) and methylcobalamin (methylated B12) provides the essential cofactors required for proper SAMe function, supporting efficient methylation cycles.* The methylated forms ensure enhanced bioavailability.

What factors may increase the need for SAMe supplementation?

The natural aging process, dietary deficiency of methionine, folate, vitamins B12 and B6 (including poor protein intake and vegan/vegetarian diets), inflammatory states, emotional and physical stressors, and genetic variants all contribute to suboptimal levels of SAMe and may increase demand for this essential compound.*

Who may benefit most from SAMe?

Individuals seeking brain function, memory, and balanced mood support, those wanting methylation support for neurotransmitters, hormones, and detoxification, people needing liver function and antioxidant status support, and anyone with increased SAMe demand due to aging, dietary factors, stress, or genetic variants.*

Practitioner Reference

SAMe is positioned within the Designs for Health Stress/Mood category. Available as SAM030 (30 vegetarian capsules) and SAM090 (90 vegetarian capsules). This product is intended for use under the guidance of a licensed health-care practitioner.