SPM Supreme

Synergistic Blend of Three Specialized Pro-Resolving Mediators (SPMs, 300 mcg Including 18-HEPE, 17-HDHA, and 14-HDHA) with Omega-3 Fatty Acids (EPA 150 mg, DHA 120 mg) from Active Fractionated Marine Lipid Concentrate (600 mg) for Normal Inflammatory Response, Tissue Repair, Normal Pain Response, and Muscle and Joint Comfort*

Key Performance Benefits

• Supports a normal inflammatory response*

• Promotes the body's normal tissue repair processes*

• Promotes a normal pain response*

• May provide support for occasional muscle and joint discomfort*

• Supports a quick return to everyday activities after physical stress*

• Provides direct, pre-formed pro-resolving mediators alongside omega-3 substrate*

What This Product Is

SPM Supreme supports the body's normal repair process, helping to promote a quick return to everyday activities.* This product may be supportive after times of physical injury or while the body is under stresses caused by poor diet, stress, or the natural aging process.* SPM Supreme offers a synergistic blend of omega-3 fatty acids (EPA and DHA) and three specialized pro-resolving mediators (SPMs) to support a normal inflammatory response.* It is uniquely positioned to promote a normal pain response and support healthy inflammatory responses.*

Specialized pro-resolving mediators are signaling compounds the body produces from the omega-3 fatty acids EPA and DHA, and they are found naturally in human milk, blood, and brain tissue. The inflammatory response is a normal and necessary part of the body's defense and repair system, but it is meant to be self-limiting — once its job is done, the body actively switches it off and begins to heal. SPMs are the molecules that orchestrate this resolution phase, signaling the body to clear cellular debris, calm the response, and move toward tissue repair. They are produced in response to inflammation or stress and may promote normal tissue repair.*

Each 2-softgel serving provides 600 mg of active fractionated marine lipid concentrate delivering 360 mg total omega-3 fatty acids (150 mg EPA, 120 mg DHA) and 300 mcg total pro-resolving mediators, including 18-hydroxyeicosapentaenoic acid (18-HEPE), 17-hydroxydocosahexaenoic acid (17-HDHA), and 14-hydroxydocosahexaenoic acid (14-HDHA). By supplying both pre-formed SPMs and the omega-3 building blocks the body uses to make more, SPM Supreme provides targeted support precisely when the body's own production may fall short.*

Mechanism of Action

Specialized Pro-Resolving Mediators (SPMs)

SPMs (300 mcg including 18-HEPE, 17-HDHA, and 14-HDHA) are derived from EPA and DHA through a complex, multi-step conversion process in the body. However, insufficient body stores of EPA and DHA, along with factors like age, stress, and certain health conditions, may alter their normal production. Supplementing with pre-formed SPMs actively promotes a healthy inflammatory response, normal tissue repair, and the body's natural responses to injury or stress.*

Omega-3 Fatty Acids (EPA and DHA)

Omega-3 fatty acids (360 mg total: EPA 150 mg, DHA 120 mg) are essential fats found in seafood sources like salmon, sardines, herring, anchovies, and mackerel. EPA and DHA serve as the precursors for SPM production and also independently support a normal inflammatory response.* The combination provides both direct SPM supplementation and the substrate needed for continued endogenous SPM production, which is especially relevant for those who do not regularly consume oily fish.

Resolution and the Return to Balance*

Where omega-3 supplementation alone supplies raw material, SPM Supreme supplies the finished signaling molecules that help drive the resolution phase of the inflammatory response directly.* This dual approach supports the body's ability to complete the repair cycle, promote a normal pain response, and provide support for occasional muscle and joint discomfort, helping the body return to its normal balanced state and everyday activities.*

Applications

• Individuals seeking inflammatory response support after physical injury or stress*

• Those wanting tissue repair support for a quick return to everyday activities*

• Individuals experiencing occasional muscle and joint discomfort

• Those seeking normal pain response support*

• Individuals wanting SPM supplementation alongside omega-3 fatty acids*

• Those who do not regularly consume oily fish such as salmon, sardines, or mackerel*

Key Ingredients / Formula Highlights

Three Pro-Resolving Mediators

SPMs (300 mcg): 18-HEPE, 17-HDHA, and 14-HDHA for inflammatory response resolution and tissue repair. Delivered in an active fractionated marine lipid concentrate (600 mg) standardized to provide meaningful, consistent amounts of these pre-formed mediators in every serving.

Omega-3 Substrate (EPA and DHA)

EPA (150 mg) and DHA (120 mg) from the same marine lipid concentrate provide the omega-3 substrate the body uses for ongoing endogenous SPM production, complementing the pre-formed mediators.

Marine-Sourced Softgels

Contains fish (anchovy, sardine, mackerel, and herring). Available as SPM060 (60 softgels). Gluten-free, soy-free, and non-GMO.

Suggested Use

Take 2 softgels per day or as directed by your health-care practitioner.

Product Questions

How does SPM Supreme differ from standard fish oil supplements?

Standard fish oil supplements provide EPA and DHA, which the body must convert into SPMs through a complex, multi-step process. SPM Supreme provides pre-formed SPMs (300 mcg of 18-HEPE, 17-HDHA, and 14-HDHA) alongside omega-3 fatty acids, offering both direct SPM supplementation and the substrate for continued endogenous production. This is particularly beneficial when the body's SPM conversion may be compromised by age, stress, or health conditions.*

What are pro-resolving mediators and why do they matter?

Pro-resolving mediators are signaling molecules the body naturally makes from omega-3 fatty acids to guide the resolution phase of a normal inflammatory response — the stage where the body clears debris, calms the response, and begins repairing tissue. Adequate SPM activity is part of how a healthy inflammatory process resolves on its own rather than lingering, which is central to the body's normal recovery and tissue repair.

When is SPM Supreme most beneficial?

SPM Supreme may be especially supportive after times of physical injury or while the body is under stresses caused by poor diet, stress, or the natural aging process.* SPMs are produced in response to inflammation or stress and promote normal tissue repair, helping to support a quick return to everyday activities.*

Who may benefit most from SPM Supreme?

Individuals seeking inflammatory response support and tissue repair after physical injury or stress, those experiencing occasional muscle and joint discomfort, people wanting direct SPM supplementation alongside omega-3 fatty acids, and anyone whose endogenous SPM production may be compromised by aging, stress, or health conditions.*

Practitioner Reference

SPM Supreme™ is positioned within the Designs for Health Cytokine Support category. Available as SPM060 (60 softgels). Contains fish (anchovy, sardine, mackerel, and herring). This product is intended for use under the guidance of a licensed health-care practitioner.