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Tri-Butyrin Supreme™
Highly Potent Butyrate | Post-biotic
Delivers a unique fusion of three butyrate molecules. Butyrate is a short-chain fatty acid that supports gut barrier integrity, immune function, and regular bowel movements.*
Features 300 mg of tributyrin (as CoreBiome™), which has the ability to deliver butyrate to the colon compared to sodium butyrate.*
• Supports a strong gut lining and a healthy balance of gut bacteria*
• Provides quick energy to fuel the gut-brain axis*
• Supports gut-associated immune function*
• May help occasional constipation by promoting regular bowel movements*
Recommended Use: Take 1 softgel per day or as directed by your health-care practitioner.
Support gut health with postbiotics*
Gut health doesn’t stop with pre- and probiotics. Tri-Butyrin Supreme™ represents a new approach to gut health and immune function — powered by postbiotics.* "Postbiotics” are health-promoting compounds produced by friendly gut microbes when they break down and ferment dietary fiber. This product is also enhanced with black cumin seed oil and medium-chain triglycerides for superior absorption.
Helpful Product Resources
Compare Tri-Butyrin Supreme™ with all Designs for Health products, review research and education resources, or visit the product and ordering FAQs for additional support.
Tri-Butyrin Supreme™ is a postbiotic gut health supplement by Designs for Health that delivers butyrate — a compound that serves as fuel for cells in the colon.* It supports gut lining health, immune function, healthy gut balance, and bowel regularity, with 300 mg of butyrate per softgel.*
Tri-Butyrin Supreme™ is specifically formulated to support gut lining health.* Butyrate helps nourish the cells that line the colon, supporting a strong gut barrier, healthy digestive function, and regular bowel movements.* Individual results may vary based on diet and overall gut health status.*
Key benefits include support for gut lining integrity, bowel regularity, healthy gut balance, gut immune function, and digestive comfort.* These are delivered through a targeted triple-butyrate compound enhanced with black cumin seed oil and MCTs for better absorption.*
Take one softgel per day, or as directed by your healthcare practitioner. Tri-Butyrin Supreme™ provides convenient once-daily postbiotic support.* For best results, use consistently as part of your gut health routine alongside pre- and probiotics.*
Tri-Butyrin Supreme™ provides butyrate in a special triple-butyrate form, delivering 300 mg of butyrate per softgel. This form has the ability to deliver butyrate to the colon compared to other forms found in commercial products, such as sodium butyrate.* It also includes black cumin seed oil and MCTs to support absorption.*
You may notice support for normal bowel regularity, digestive comfort, and overall gut wellness with consistent use.* Butyrate acts as fuel for colon cells and supports the gut barrier from within.* Results depend on your diet, fiber intake, current gut health, probiotic use, and consistency of supplementation.*
Tri-Butyrin Supreme™ is designed for daily use when taken as directed.* It may be especially ideal for individuals who cannot tolerate dietary fiber but still need postbiotic gut support.* Consult your healthcare practitioner before use if you are pregnant, nursing, or managing a health condition.*
Fiber and probiotics help the body produce butyrate indirectly through fermentation.* Tri-Butyrin Supreme™ delivers butyrate directly, making it a convenient option for those who want postbiotic gut support without adding more fiber to their routine.*
Tri-Butyrin Supreme™
Tributyrin (as CoreBiome™, 300 mg) Triple Butyrate Postbiotic with Black Cumin Seed Oil and Medium Chain Triglycerides for Gut Barrier Integrity, Bowel Regularity, Healthy Immune and Inflammatory Responses, Butyrate Status in the Large Intestine, and Gut Microbial Diversity*
Key Performance Benefits
- Promotes gastrointestinal health*
- May help support healthy butyrate status in the large intestine*
- Promotes healthy immune and inflammatory responses*
- May help support bowel regularity*
- Helps support gut microbial diversity*
What This Product Is
Tri-Butyrin Supreme provides 300 mg of tributyrin (as CoreBiome™), a unique fusion of three butyrate molecules attached to glycerol. Butyrate is a short-chain fatty acid, or special type of fat, that supports gut barrier integrity, regularity, healthy immune responses, and overall well-being.* It is the preferred energy source for the cells of the large intestine, and it may support healthy gut microbial balance.*
Gut health does not stop with pre- and probiotics. Postbiotics are health-promoting compounds produced by friendly gut microbes when they break down and ferment dietary fiber. Tri-Butyrin Supreme completes the gut health regimen with butyrate, the ultimate postbiotic solution. A greater percentage of the tributyrin form of butyrate can make it to the large intestine compared to sodium butyrate, and combining it with black cumin seed oil and medium chain triglycerides supports superior absorption.*
Mechanism of Action
Tributyrin Triple Butyrate Delivery
Tributyrin (CoreBiome™, 300 mg) is a targeted form that fuses three butyrate molecules attached to glycerol. This structure allows a greater percentage of butyrate to reach the large intestine compared to sodium butyrate, providing efficient delivery to the cells that use it as their preferred energy source. Butyrate supports gut barrier integrity, healthy immune responses, and microbial diversity.*
Black Cumin Seed Oil and MCT Enhancement
The combination with black cumin seed oil (Nigella sativa) and medium chain triglycerides supports superior absorption of the tributyrin. This formulation may be especially beneficial for individuals who cannot tolerate dietary fiber, providing postbiotic butyrate support through direct supplementation rather than relying solely on microbial fermentation of fiber.*
Applications
- Individuals seeking postbiotic gut health support beyond pre- and probiotics*
- Those wanting to support healthy butyrate status in the large intestine*
- Individuals needing gut barrier integrity and bowel regularity support*
- Those who cannot tolerate dietary fiber but need butyrate support*
- Individuals seeking healthy immune and inflammatory response support through gut health*
Key Ingredients / Formula Highlights
CoreBiome™ Tributyrin
Tributyrin (300 mg) as CoreBiome™ — three butyrate molecules attached to glycerol. Greater percentage reaches the large intestine compared to sodium butyrate. Combined with black cumin seed oil and medium chain triglycerides for superior absorption.
Complete Postbiotic Softgel
Available as TBS060 (60 softgels). Store at room temperature; heat sensitive. Gluten-free, soy-free. Non-GMO.
Suggested Use
Take 1 softgel per day or as directed by your health-care practitioner.
Product Questions
How does tributyrin differ from sodium butyrate?
Tributyrin is a unique fusion of three butyrate molecules attached to glycerol, while sodium butyrate is a single butyrate molecule paired with sodium. A greater percentage of the tributyrin form can make it to the large intestine compared to sodium butyrate, providing more efficient delivery of butyrate to the cells that need it most. Tri-Butyrin Supreme further enhances this with black cumin seed oil and medium chain triglycerides for superior absorption.*
What is a postbiotic and why is butyrate important?
Postbiotics are health-promoting compounds produced by friendly gut microbes when they break down and ferment dietary fiber. Butyrate is a short-chain fatty acid that is the preferred energy source for the cells of the large intestine. It supports gut barrier integrity, regularity, healthy immune responses, and gut microbial diversity.* Tri-Butyrin Supreme provides butyrate directly, which may be especially beneficial for individuals who cannot tolerate dietary fiber.*
Who may benefit most from Tri-Butyrin Supreme?
Individuals seeking comprehensive postbiotic gut health support beyond pre- and probiotics, those wanting to support butyrate status in the large intestine for gut barrier integrity and regularity, people who cannot tolerate dietary fiber but need butyrate support, and anyone seeking healthy immune and inflammatory response support through optimized gut health.*
Practitioner Reference
Tri-Butyrin Supreme™ is positioned within the Designs for Health Gastrointestinal Health category. Available as TBS060 (60 softgels). CoreBiome™ is a trademark of Compound Solutions, Inc. This product is intended for use under the guidance of a licensed health-care practitioner.