Trifolamin™

Trifolamin™ lozenges

Three Highly Bioavailable Forms of Vitamin B12 (3,000 mcg as Methylcobalamin, Hydroxycobalamin, and Adenosylcobalamin) Plus Folate (680 mcg as [6S]-5-Methyltetrahydrofolate / 5-MTHF) in an Orange-Flavored Lozenge for Healthy B12 Levels, Neurological Health, Cellular Energy Metabolism, Cellular Repair, Cognition, Mood, and Fetal Development*

Key Performance Benefits

• Supports healthy levels of vitamin B12*

• Promotes neurological health*

• Supports healthy cellular energy metabolism*

• Promotes cellular repair and function*

• Promotes healthy cognition and mood*

• Supports healthy fetal development*

What This Product Is

Trifolamin is a synergistic combination of three bioavailable forms of vitamin B12, including methylcobalamin, hydroxycobalamin, and adenosylcobalamin, with a patented active form of folate as [6S]-5-methyltetrahydrofolate (5-MTHF). Vitamin B12, also known as cobalamin, is a water-soluble micronutrient that is essential for cellular repair and function, cellular energy metabolism, and neurological function.* It is not produced by humans and must be obtained from dietary sources or supplementation.

The ingredients in Trifolamin support methylation reactions, which provide critical functions for DNA synthesis and repair, cellular energy metabolism, nerve cell structure and function, and red blood cell production.* Folate and vitamin B12 are also essential for the regulation of homocysteine levels, which play a role in cardiovascular health.* The lozenge delivery system allows for absorption to begin upon ingestion as well as binding by a salivary protein that carries vitamin B12 to the gastrointestinal tract for superior absorption.

Mechanism of Action

Triple B12 with Bioidentical Folate for Methylation Support*

Three forms of vitamin B12 (3,000 mcg total as methylcobalamin, hydroxycobalamin, and adenosylcobalamin) provide comprehensive B12 support using naturally occurring forms more bioavailable than synthetic cyanocobalamin. The bioidentical form of folate (680 mcg as 5-MTHF) is ideal for supplementation, especially for individuals with genetic variations affecting folic acid conversion, and works synergistically with B12 in methylation pathways.

Lozenge Delivery for Superior Absorption

The lozenge delivery system of Trifolamin allows for absorption to begin upon ingestion through the oral mucosa, as well as being bound by a protein secreted in the saliva that carries vitamin B12 to the gastrointestinal tract. This dual absorption pathway supports optimal B12 and folate utilization for neurological and cellular health.* The lozenges are great-tasting orange-flavored with no artificial sweeteners and are suitable for vegans.

Applications

• Individuals seeking combined B12 and folate support for methylation and homocysteine regulation*

• Those wanting neurological health, cognition, and mood support*

• Women of childbearing age needing folate for healthy fetal development*

• Vegans and vegetarians needing B12 supplementation from non-animal sources*

• Individuals with genetic variations affecting folate or B12 metabolism*

Key Ingredients / Formula Highlights

Triple B12 Plus Folate

Vitamin B12 (3,000 mcg) as methylcobalamin, hydroxycobalamin, and adenosylcobalamin. Folate (680 mcg) as [6S]-5-methyltetrahydrofolate (5-MTHF) — bioidentical active form.

Vegan Lozenge Format

Orange-flavored lozenge for oral and GI absorption. No artificial sweeteners. Suitable for vegans. Available as TRIF60 (60 lozenges). Gluten-free, dairy-free, soy-free. Non-GMO.

Suggested Use

Take 1 lozenge per day or as directed by your health-care practitioner. Allow lozenge to dissolve slowly and completely in mouth and swallow.

Product Questions

How does Trifolamin compare to Tricobalamin?

Trifolamin combines three forms of vitamin B12 (3,000 mcg) with folate (680 mcg as 5-MTHF) for synergistic methylation, homocysteine regulation, neurological health, and fetal development support. Tricobalamin provides the same three forms of B12 (3,000 mcg) without folate, focused on B12 status and nervous system support. Choose Trifolamin when both B12 and folate support are needed, or Tricobalamin for targeted B12 supplementation alone.*

Why is the 5-MTHF form of folate important?

The form of folate (5-MTHF) in Trifolamin is a bioidentical form that is ideal for supplementation. Unlike synthetic folic acid used in most supplements, 5-MTHF does not require enzymatic conversion before the body can use it. This is especially important for individuals with genetic variations affecting folate metabolism, as these individuals may not efficiently convert folic acid into its active form.*

Who may benefit most from Trifolamin?

Individuals seeking synergistic B12 and folate support for methylation and homocysteine regulation, those wanting neurological health, cognition, and mood support, women of childbearing age needing active folate for fetal development, vegans needing B12 supplementation, and anyone with genetic variations affecting folate or B12 metabolism who needs bioavailable nutrient forms in a convenient lozenge.*

Practitioner Reference

Trifolamin™ is positioned within the Designs for Health Foundational Health category. Available as TRIF60 (60 lozenges). Gluten-free, dairy-free, soy-free. Non-GMO. Suitable for vegans. This product is intended for use under the guidance of a licensed health-care practitioner.